| Type | Description |
|---|---|
| Definition | SOS Ras/Rac guanine nucleotide exchange factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:37:00 | SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations. | 32752665 |
| 2020-11-21 13:29:00 | Molecular Dynamics model of peptide-protein conjugation: case study of covalent complex between Sos1 peptide and N-terminal SH3 domain from Grb2. | 31882608 |
| 2020-08-12 13:02:00 | six patients with SOS1 variants and Congenital heart defects and cardiomyopathy (male to female ratio 2:1) including two novel variants, were identified. | 31368652 |
| 2020-04-04 11:37:00 | Enhanced expression of SOS1 is associated with uveal malignant melanoma. | 30714452 |
| 2020-01-11 11:59:00 | Transcriptional profiling reveals that the expression of mutant SOS1 leads to the upregulation of MYC target genes and genes associated with Ras transformation. | 30635434 |
| Type | IDs |
|---|---|
| Synonymous | GF1, GGF1, GINGF, HGF, NS4, SOS-1 |
| Gene |
UniProtKB-ID:
SOS1_HUMAN,
G5E9C8_HUMAN
UniprotKB:
Q07889,
G5E9C8
UniParc:
UPI0000E5A254,
UPI00017A812A,
UPI0000135CF0
EMBL:
AK301960,
CH471053,
AC019171,
AC092672,
AK290228,
L13857
Ensembl:
ENSG00000115904
KO:
hsa:6654
|
| Nucleutide sequences |
EMBL-CDS:
BAG63374.1,
EAX00351.1,
BAF82917.1,
AAA35913.1,
EAX00353.1
Gene_ORFName:
hCG_1641052
Ensembl_TRS:
ENST00000402219,
ENST00000395038
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000384675,
ENSP00000378479
RefSeq:
NP_001369324.1,
NP_001369323.1,
XP_011531366.1,
NP_005624.2
|
| Others |
UniRef100:
UniRef100_Q07889,
UniRef100_G5E9C8
UniRef90:
UniRef90_A0A4W2ICE3,
UniRef90_Q07889
UniRef50:
UniRef50_G1TRT1,
UniRef50_Q07889
UniGene:
Hs.709893,
Hs.732497
CCDS:
CCDS1802.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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