| Type | Description |
|---|---|
| Definition | nicotinamide nucleotide adenylyltransferase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:31:00 | SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration. | 33107823 |
| 2019-11-16 10:41:00 | The present study found that Nmnat1 is essential for the early development of the retina, particularly for the survival of retinal progenitor cells that are fated to retinal subtypes in the inner nuclear layer. | 30166529 |
| 2019-01-12 11:05:00 | We propose that the E257K allele is a weak hypomorphic allele that has significantly reduced penetrance in the homozygous state. In contrast, compound heterozygous Nmnat1(E257K/-) mice exhibit photoreceptor defects which are exacerbated upon exposure to light. | 29674119 |
| 2018-08-11 11:17:00 | that increasing NMNAT1 levels can slow the progression of symptoms and neuropathological features of tauopathy | 29175372 |
| 2017-11-25 15:09:00 | Using steady-state and flux analysis of NAD(+) metabolites in healthy and injured mouse dorsal root ganglion axons, we find that rather than altering NAD(+) synthesis, NMNAT1 instead blocks the injury-induced, SARM1-dependent NAD(+) consumption that is central to axon degeneration. | 27735788 |
| Type | IDs |
|---|---|
| Synonymous | 2610529L11Rik, 5730441G13Rik, D4Cole1e, nmnat |
| Gene |
UniProtKB-ID:
NMNA1_MOUSE,
Q3V449_MOUSE
UniprotKB:
Q9EPA7,
Q3V449
UniParc:
UPI000019A62D
EMBL:
AF260924,
BC138500,
AK012194,
AY679721,
AF260925,
BC138502,
AF260927
Ensembl:
ENSMUSG00000028992
KO:
mmu:66454
|
| Nucleutide sequences |
EMBL-CDS:
AAG17286.1,
AAG17285.1,
AAG38490.1,
AAT76443.1,
AAI38503.1,
AAI38501.1,
BAE43229.1
Ensembl_TRS:
ENSMUST00000105693,
ENSMUST00000030845
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000030845,
ENSMUSP00000101318
RefSeq:
NP_597679.1,
NP_001343286.1
|
| Others |
UniRef100:
UniRef100_Q9EPA7
UniRef90:
UniRef90_Q9EPA7
UniRef50:
UniRef50_Q9EPA7
UniGene:
Mm.76062
CCDS:
CCDS18960.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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