| Type | Description |
|---|---|
| Definition | interferon induced transmembrane protein 3 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:56:00 | The innate immunity protein IFITM3 modulates gamma-secretase in Alzheimer's disease. | 32879487 |
| 2020-04-11 10:48:00 | IFITM3 deficiency in a new knockout (KO) mouse model increases weight loss and mortality following influenza virus infections. Infected IFITM3 KO mice developed aberrant cardiac electrical activity, including decreased heart rate and irregular, arrhythmic RR (interbeat) intervals. Findings reveal an essential role for IFITM3 in limiting influenza virus replication and pathogenesis in heart tissue. | 31451661 |
| 2019-09-28 11:08:00 | Study in influenza virus infection mouse models found that Ifitm3 is rapidly up-regulated by T cells following their activation and this occurred independently of type I and II interferon and the interferon regulatory factors 3 and 7. Up-regulation of Ifitm3 on effector T cells protected these cells from virus infection and imparted a survival advantage at sites of virus infection. | 30650117 |
| 2019-06-01 10:27:00 | this study shows that IFITM3 drives type 2 T helper cell differentiation and exacerbate allergic airway inflammation | 30365177 |
| 2019-01-19 10:49:00 | the role of IFITM3 in colonic epithelial homeostasis, inflammation and colitis-associated tumorigenesis using IFITM3-deficient mice, was investigated. | 29356071 |
| Type | IDs |
|---|---|
| Synonymous | 1110004C05Rik, Cd225, Cdw217, DSPA2b, Fgls, IP15, mil-1 |
| Gene |
UniProtKB-ID:
IFM3_MOUSE
UniprotKB:
Q9CQW9
UniParc:
UPI000002263D
EMBL:
AK151890,
AK007916,
BC010291,
AY082484,
AK003407,
AK007919,
CH466531,
AY594690
Ensembl:
ENSMUSG00000025492
KO:
mmu:66141
|
| Nucleutide sequences |
EMBL-CDS:
AAH10291.1,
AAM03316.1,
BAB25350.1,
EDL17977.1,
BAB25347.1,
BAE30774.1,
AAT06089.1,
BAB22771.1
Ensembl_TRS:
ENSMUST00000026565
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000026565
RefSeq:
NP_079654.1
|
| Others |
UniRef100:
UniRef100_Q9CQW9
UniRef90:
UniRef90_Q9CQW9
UniRef50:
UniRef50_Q9CQW9
UniGene:
Mm.141021
CCDS:
CCDS21996.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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