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66002 CYP4F12

66002

CYP4F12

cytochrome P450 family 4 subfamily F member 12

protein-coding

Homo sapiens

基因描述

Type Description
Definition cytochrome P450 family 4 subfamily F member 12

研究结论

Date Results Publications
2018-08-18 10:42:00 These results suggest that human and marmoset P450 3A4/90 and 4F12 in livers or small intestines played important roles in terfenadine t-butyl hydroxylation. Marmosets could be a model for humans during first pass extraction of terfenadine and related substrates. 28436281
2016-07-16 10:35:00 Our results showed that HCV infection induced expression of CYP4F12 protein, which bound to the HCV replication complex to facilitate viral replication. 26845356
2010-01-21 00:00:00 3-hydroxystearate and 3-hydroxypalmitate are converted to omega-hydroxylated 3-OHDCA precursors in liver; CYP4F11 and, to a lesser extent, CYP4F2 catalyzed omega-hydroxylation of 3-hydroxystearate; CYP4F3b, CYP4F12, and CYP4A11 had negligible activity. 18065749
2010-01-21 00:00:00 We conclude that CYP4F8 and CYP4F12 catalyze epoxidation of 22:6n-3 and 22:5n-3, and CYP4F8 omega3-hydroxylation of 22:5n-6. 16112640

名称对应

Type IDs
Synonymous CYPIVF12, F22329_1
Gene
UniProtKB-ID: CP4FC_HUMAN
UniprotKB: Q9HCS2
UniParc: UPI00020B9EFD, UPI0001AE63A4
EMBL: KF459712.1, CH471106, AB035130, AL832171, AC004523, AC122702, AK075435, AY358977, AY008841, AB035131
Ensembl: ENSG00000186204
KO: hsa:66002
Nucleutide sequences
EMBL-CDS: EAW84492.1, CAI46131.1, AAQ89336.1, BAB18269.1, BAB18270.1, AAC11543.1, EAW84495.1, AAG33247.1, BAG52137.1
Gene_ORFName: UNQ568/PRO1129
Ensembl_TRS: ENST00000548435, ENST00000324632, ENST00000517734, ENST00000550308
Protein sequencees
Ensembl_PRO: ENSP00000430849, ENSP00000448998, ENSP00000449703, ENSP00000321821
RefSeq: XP_011526504.1, XP_011526505.1, XP_011526506.1, XP_011526509.1, XP_016882661.1, NP_076433.3, XP_006722913.1, XP_011526507.1, XP_011526510.1
Others
UniRef100: UniRef100_Q9HCS2
UniRef90: UniRef90_Q9HCS2
UniRef50: UniRef50_P78329
UniGene: Hs.131459
CCDS: CCDS42517.1

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