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660 BMX

660

BMX

BMX non-receptor tyrosine kinase

protein-coding

Homo sapiens

基因描述

Type Description
Definition BMX non-receptor tyrosine kinase

研究结论

Date Results Publications
2020-04-18 11:52:00 Linc00173 upregulated Etk through functioning as a competitive endogenous RNA (ceRNA) by "sponging" miRNA-218 and led to the upregulation of GSKIP and NDRG1, resulting in the translocation of beta-catenin. Importantly, expression analysis revealed that both Linc00173 and Etk were upregulated in SCLC patient samples and exhibiting positive Linc00173/Etk correlation 31477834
2020-02-29 12:13:00 The upregulation of the fusion gene BMX-ARHGAP promoted epithelial-mesenchymal transition in gastric cancer cells by activating the RhoA and axis. 30216523
2019-10-12 10:04:00 tyrosine kinase BMX is negatively regulated by androgen and contributes to castration-resistant prostate cancer by enhancing the phosphorylation and activation of multiple receptor tyrosine kinases following androgen deprivation therapy 30012673
2019-09-28 10:13:00 Epithelial and endothelial tyrosine kinase (Etk) interacts with 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) to promote small-cell lung cancer (SCLC) chemoresistance through regulation of autophagy. 29208667
2019-05-11 11:57:00 results demonstrate that hypoxia-dependent upregulation of BMX contributes to therapeutic resistance through a compensatory prosurvival signaling mechanism. These results also reveal the role of off-target drug effects on tumor microenvironment and development of acquired drug resistance. 29227282

名称对应

Type IDs
Synonymous ETK, PSCTK2, PSCTK3
Gene
UniProtKB-ID: BMX_HUMAN
UniprotKB: P51813
UniParc: UPI0000000DFF
EMBL: BC016652, AC097625, U08341, CH471074, AF045459, X83107
Ensembl: ENSG00000102010
KO: hsa:660
Nucleutide sequences
EMBL-CDS: AAC08966.1, CAA58169.1, AAH16652.1, EAW98889.1, AAA17744.1
Ensembl_TRS: ENST00000357607, ENST00000342014, ENST00000348343
Protein sequencees
Ensembl_PRO: ENSP00000308774, ENSP00000350224, ENSP00000340082
RefSeq: NP_975010.1, XP_016885241.1, NP_001712.1, NP_001307795.1
Others
UniRef100: UniRef100_P51813
UniRef90: UniRef90_P51813
UniRef50: UniRef50_P51813
UniGene: Hs.495731
CCDS: CCDS14168.1

全选

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