| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase kinase 20 |
| Date | Results | Publications |
|---|---|---|
| 2017-11-11 11:55:00 | Zak-/- mice demonstrate a distinct ribotoxic stress-associated phenotype in response to ricin. | 27598200 |
| 2016-10-22 10:42:00 | ZAK is a key player in mammalian limb patterning in humans and mice. | 26755636 |
| 2015-07-04 12:30:00 | Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions. | 24789282 |
| 2010-01-21 00:00:00 | Mixed lineage kinase 7 (MLK7), a splice variant of the human ZAK gene (ortholog of mouse B230120H23Rik), encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation. | 15737997 |
| 2010-01-21 00:00:00 | PKNalpha functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein for the p38gamma MAPK signaling pathway | 12761180 |
| Type | IDs |
|---|---|
| Synonymous | AV006891, B230120H23Rik, HCCS-4, MLTK, MLTKalpha, MLTKbeta, Zak |
| Gene |
UniProtKB-ID:
M3K20_MOUSE,
Q3TRG2_MOUSE
UniprotKB:
Q9ESL4,
Q3TRG2
UniParc:
UPI000002784D,
UPI0000022AE0,
UPI00001EF269
EMBL:
AB049732,
AK162819,
AK045444,
AB049731,
AK132186,
BC023718
Ensembl:
ENSMUSG00000004085
KO:
mmu:65964
|
| Nucleutide sequences |
EMBL-CDS:
BAE21021.1,
AAH23718.1,
BAB16442.1,
BAB16443.1,
BAC32371.1,
BAE37068.1
Ensembl_TRS:
ENSMUST00000090824,
ENSMUST00000135469
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000088334,
ENSMUSP00000118983
RefSeq:
NP_001158263.1,
NP_835185.2,
XP_030107797.1,
XP_006500060.1,
XP_006500061.1,
NP_075544.1
|
| Others |
UniRef100:
UniRef100_Q9ESL4,
UniRef100_Q3TRG2
UniRef90:
UniRef90_D4AE17,
UniRef90_Q9ESL4
UniRef50:
UniRef50_Q9NYL2,
UniRef50_D4AE17
UniGene:
Mm.304143,
Mm.314618
CCDS:
CCDS38143.1,
CCDS50605.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32325033 |
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst Reza Pourhaghighi , Peter E A Ash , Sadhna Phanse , Florian Goebels , Lucas Z M Hu , Siwei Chen , Yingying Zhang , Shayne D Wierbowski , Samantha Boudeau , Mohamed T Moutaoufik , Ramy H Malty , Edyta Malolepsza , Kalliopi Tsafou , Aparna Nathan , Graham Cromar , Hongbo Guo , Ali Al Abdullatif , Daniel J Apicco , Lindsay A Becker , Aaron D Gitler , Stefan M Pulst , Ahmed Youssef , Ryan Hekman , Pierre C Havugimana , Carl A White , Benjamin C Blum , Antonia Ratti , Camron D Bryant , John Parkinson , Kasper Lage , Mohan Babu , Haiyuan Yu , Gary D Bader , Benjamin Wolozin , Andrew Emili |
2020-04-22 | - |
| 27598200 |
A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response. Toxins (Basel) Dakshina M Jandhyala , John Wong , Nicholas J Mantis , Bruce E Magun , John M Leong , Cheleste M Thorpe |
2016-09-02 | - |
| 27113764 |
The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. EMBO Rep Beezly S Groh , Feng Yan , Matthew D Smith , Yanbao Yu , Xian Chen , Yue Xiong |
2016-05-01 | - |
| 26755636 |
Genome Res Malte Spielmann , Naseebullah Kakar , Naeimeh Tayebi , Catherine Leettola , Gudrun Nürnberg , Nadine Sowada , DarÃo G Lupiáñez , Izabela Harabula , Ricarda Flöttmann , Denise Horn , Wing Lee Chan , Lars Wittler , Rüstem Yilmaz , Janine Altmüller , Holger Thiele , Hans van Bokhoven , Charles E Schwartz , Peter Nürnberg , James U Bowie , Jamil Ahmad , Christian Kubisch , Stefan Mundlos , Guntram Borck |
2016-02-01 | - |
| 24789282 |
PLoS ONE Misato Kobayashi , Tamio Ohno , Kunio Ihara , Atsushi Murai , Mayumi Kumazawa , Hiromi Hoshino , Koichiro Iwanaga , Hiroshi Iwai , Yoshiki Hamana , Mikako Ito , Kinji Ohno , Fumihiko Horio |
2014-01-01 |
Itga6,
Mtx2,
Zak,
Gpr155
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 18287559 |
GUDMAP: the genitourinary developmental molecular anatomy project. J Am Soc Nephrol Andrew P McMahon , Bruce J Aronow , Duncan R Davidson , Jamie A Davies , Kevin W Gaido , Sean Grimmond , James L Lessard , Melissa H Little , S Steven Potter , Elizabeth L Wilder , Pumin Zhang , GUDMAP project |
2008-04-01 | - |
| 18554416 |
Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. Brad G Hoffman , Bogard Zavaglia , Joy Witzsche , Teresa Ruiz de Algara , Mike Beach , Pamela A Hoodless , Steven J M Jones , Marco A Marra , Cheryl D Helgason |
2008-01-01 |
Fam174b,
Ugt2b34,
Emilin1,
Akap9,
Hepacam2,
Cyp4v3,
Lars2,
Gck,
Acly,
Ces1d,
Mycbpap,
Fam110c,
Card10,
Arap3,
Fam111a,
Ssr1,
Ankrd1,
Ltbp4,
Cald1,
Ctrl,
Cpa1,
Clps,
Vimp,
Cela1,
Fgb,
Rap1gap,
Acadl,
Ace,
Acp5,
Chrna1,
Tle6,
Actc1,
Actn2,
Acta2,
Adamts1,
Adcy7,
Plin2,
Afp,
Alcam,
Ambp,
Mat1a,
Amy1,
Anxa3,
Anxa4,
Ap1g2,
Aplp1,
Apoa1,
Apoa2,
Aqp1,
Arc,
Arg1,
Arx,
Ass1,
Neurod4,
Neurog3,
Atp2a2,
Bcap29,
Bex2,
Bgn,
Klf5,
Btg2,
Btk,
Serping1,
Calca,
Calm1,
Calm2,
Casp3,
Serpina6,
Cck,
Cckar,
Cd2ap,
Cd34,
Cd44,
Cdk11b,
Cdh1,
Cdkn1a,
Cdkn1c,
Cel,
Cfh,
Chga,
Chgb,
Cited1,
Cldn3,
Clu,
Cnih1,
Plk3,
Col14a1,
Col15a1,
Col3a1,
Col5a2,
Col6a1,
Col9a2,
Col1a1,
Col1a2,
Coq7,
Cox6a2,
Crabp2,
Cryba2,
Dnajc5
|
| 16141073 |
Antisense transcription in the mammalian transcriptome. Science S Katayama , Y Tomaru , T Kasukawa , K Waki , M Nakanishi , M Nakamura , H Nishida , C C Yap , M Suzuki , J Kawai , H Suzuki , P Carninci , Y Hayashizaki , C Wells , M Frith , T Ravasi , K C Pang , J Hallinan , J Mattick , D A Hume , L Lipovich , S Batalov , P G Engström , Y Mizuno , M A Faghihi , A Sandelin , A M Chalk , S Mottagui-Tabar , Z Liang , B Lenhard , C Wahlestedt , RIKEN Genome Exploration Research Group , Genome Science Group (Genome Network Project Core Group) , FANTOM Consortium |
2005-09-02 |
Gm14018,
Gm14964,
F630206G17Rik,
Oog3,
Notumos,
Ldlrap1,
Mdn1,
Pydc3,
9330171B17Rik,
Mfap1b,
Tmsb15b2,
Gm12802,
E430020m11rik,
Gm11335,
Gm15772,
Gm17762,
A930017K11Rik,
LOC100036513,
Gata5os,
Umad1,
Gm16982,
Gm9887,
Gm9872,
LOC100036530,
Gm9934,
Gm9913,
Gm11149,
BC028777,
Gm13999,
LOC100036540,
Gm9744,
Gm9983,
D630002J18Rik,
Gm16525,
Gm11696,
Dnajc3,
9430060I03Rik,
Gm12359,
4921516A02Rik,
Fam129c,
Gm10589,
Rsph3b,
Rnaset2a,
5430403G19Rik,
D030047H15Rik,
Gm13274,
B930046K06Rik,
Gm10862,
Gm10792,
Gm10802,
Gm10532,
G730003C15Rik,
Runx2os1,
Gm15612,
Gm10856,
Gm10857,
Gm10685,
Gm10803,
Gm10723,
F630028O10Rik,
Gm10836,
Gm10405,
Gm10513,
Gm10609,
F630201L12Rik,
4932427H20Rik,
Zfp389,
Gm10763,
Gm10062,
Gm10714,
Gm10531,
Gm10876,
Gm10750,
Gm10433,
Gm10837,
Gm10647,
Gm10648,
Gm10650,
Gm10610,
F830115B05Rik,
Gm10473,
Gm10614,
Gm10286,
G730046D07Rik,
Gm10287,
Gm10785,
Gm10183,
Gm10512,
1700061E17Rik,
Gm44113,
Gm10579,
Gm10741,
Gm10827,
Gm10522,
Gm10536,
Gm15998,
Faddos,
D130050E23Rik,
Gm10735
|
| 16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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