| Type | Description |
|---|---|
| Definition | cytosolic arginine sensor for mTORC1 subunit 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:52:00 | RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation. | 33594058 |
| 2020-05-30 13:47:00 | the KSHV-encoded miRNA miR-K4-5p, and probably miR-K1-5p, directly targeted CASTOR1 to inhibit its expression. Knockdown of miR-K1-5p and -K4-5p restored CASTOR1 expression and thereby attenuated mTORC1 activation. | 31305263 |
| 2020-03-14 12:23:00 | The binding free energy calculations revealed that Nalpha-acetyl-arginine, citrulline, and norarginine have sufficient binding affinity with CASTOR1 to compete with arginine. The hydrogen bond analysis revealed that norarginine, Nalpha-acetyl-arginine and D-arginine have proficient H-bonds that can facilitate their entering the narrow binding pocket. | 31659101 |
| 2019-11-30 10:07:00 | these findings demonstrated that CASTOR1 inhibits the tumorigenesis of lung adenocarcinoma cells and might serve as a potential therapeutic target or prognostic marker for human patients with lung adenocarcinoma. | 30132978 |
| 2019-06-08 12:57:00 | Report crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states at 2.05A and 2.8A, respectively. Structural comparison of CASTOR1 between two states reveals near identical conformations, except in two loop regions. It indicates CASTOR1 does not undergo large conformational change during arginine binding. | 30503338 |
| Type | IDs |
|---|---|
| Synonymous | GATSL3 |
| Gene |
UniProtKB-ID:
CAST1_HUMAN
UniprotKB:
Q8WTX7
UniParc:
UPI0000071943
EMBL:
BC021927,
AC004997,
CR456449,
AK055587,
CH471095
Ensembl:
ENSG00000239282
KO:
hsa:652968
|
| Nucleutide sequences |
EMBL-CDS:
AAC23432.1,
AAH21927.1,
EAW59870.1,
BAB70963.1,
AAC23433.1,
EAW59868.1,
CAG30335.1
Ensembl_TRS:
ENST00000407689
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000384183
RefSeq:
NP_001032755.1
|
| Others |
UniRef100:
UniRef100_Q8WTX7
UniRef90:
UniRef90_Q8WTX7
UniRef50:
UniRef50_Q8WTX7
UniGene:
Hs.444950
CCDS:
CCDS43001.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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