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6527 SLC5A4

6527

SLC5A4

solute carrier family 5 member 4

protein-coding

Homo sapiens

基因描述

Type Description
Definition solute carrier family 5 member 4

研究结论

Date Results Publications
2021-03-06 13:30:00 Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in obesity. 33385407
2019-04-06 11:40:00 Whole-exome sequencing (WES) of several extended pedigrees with high density of attention-deficit/hyperactivity disorder (ADHD) identified a triplet ATG deletion in SLC5A4 leading to a single amino acid loss (DeltaM500) in the hSGLT3 protein imperfectly co-segregating with the clinical phenotype of ADHD. [DeltaM500] in hSGLT3 inhibits membrane targeting and thus largely disrupts glucose-induced sodium conductance. 30286162
2015-06-06 14:06:00 Data suggest SGLT3 in neurons of portal vein wall plays role in sensing blood glucose level and in satiety response; dietary protein indirectly affects satiety response via up-regulation of intestinal gluconeogenesis and thus blood glucose. [REVIEW] 25200297
2012-12-22 10:09:00 the expression and functional role of SGLT3 in the human kidney 22766068
2011-06-18 10:35:00 hSGLT3 functions as a sugar sensor in vivo and mutating a single amino acid converts this sugar sensor into a sugar transporter similar to SGLT1. 20421923

名称对应

Type IDs
Synonymous DJ90G24.4, SAAT1, SGLT3
Gene
UniProtKB-ID: SC5A4_HUMAN
UniprotKB: Q9NY91
UniParc: UPI00001359F4
EMBL: U41897, AJ133127, AL008723
Ensembl: ENSG00000100191
KO: hsa:6527
Nucleutide sequences
EMBL-CDS: CAB81772.1, AAB61732.1
Ensembl_TRS: ENST00000266086
Protein sequencees
Ensembl_PRO: ENSP00000266086
RefSeq: XP_011528646.1, XP_011528644.1, XP_006724371.1, NP_055042.1, XP_011528645.1, XP_016884409.1
Others
UniRef100: UniRef100_Q9NY91
UniRef90: UniRef90_Q9NY91
UniRef50: UniRef50_P53792
UniGene: Hs.130101
CCDS: CCDS13903.1

全选

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研究热度

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