| Type | Description |
|---|---|
| Definition | WNK lysine deficient protein kinase 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 10:10:00 | D564N mutation in WNK4 is a novel genetic cause of PHA2 with a relatively mild phenotype. | 31044551 |
| 2020-02-29 11:41:00 | Molecular dynamics simulations indicate the effects of these mutations on the interaction between the Kelch domain of kelch-like protein 3 (KLHL3) and the acidic motif (AM) of WNK lysine deficient protein kinase 4 protein (WNK4). | 30931564 |
| 2019-11-02 12:12:00 | This study has identified specific WNK4 that are involved in opening TRPV4, using a selective screen of short interfering ribonucleic acid (siRNA) SMARTpools, which individually targeted all human kinases, in human embryonic kidney 293 (HEK293) cells that stably express inducible TRPV4. | 29148820 |
| 2019-07-13 11:40:00 | Kidney-specific WNK1 isoform is a potent activator of WNK4 and NCC-mediated sodium/chloride transport. | 29846116 |
| 2019-05-04 11:41:00 | tacrolimus increases levels of KLHL3(S433-P), resulting in increased levels of WNK4, phosphorylated and Na-Cl cotransporter.These findings demonstrate that KLHL3(S433-P) is a calcineurin substrate and implicate increased KLHL3 phosphorylation in tacrolimus-induced pathologies. | 30718414 |
| Type | IDs |
|---|---|
| Synonymous | PHA2B, PRKWNK4 |
| Gene |
UniProtKB-ID:
WNK4_HUMAN
UniprotKB:
Q96J92
UniParc:
UPI000006FC0F,
UPI0000236D78,
UPI0000236D79
EMBL:
EU332870,
AK096003,
AK096052,
AJ316534,
AF390018,
CH471152,
BC136664,
AJ309861
Ensembl:
ENSG00000126562
KO:
hsa:65266
|
| Nucleutide sequences |
EMBL-CDS:
EAW60881.1,
BAC04669.1,
BAC04688.1,
AAK91995.1,
ABY87559.1,
EAW60882.1,
CAC32991.1,
AAI36665.1,
CAC48387.1
Ensembl_TRS:
ENST00000246914
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000246914
RefSeq:
NP_001308228.1,
NP_115763.2,
XP_016880451.1,
XP_016880455.1
|
| Others |
UniRef100:
UniRef100_Q96J92
UniRef90:
UniRef90_Q96J92
UniRef50:
UniRef50_Q96J92
UniGene:
Hs.105448
CCDS:
CCDS11439.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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