| Type | Description |
|---|---|
| Definition | potassium voltage-gated channel subfamily D member 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:22:00 | Magnesium Deficiency Causes Transcriptional Downregulation of Kir2.1 and Kv4.2 Channels in Cardiomyocytes Resulting in QT Interval Prolongation. | 32554946 |
| 2020-02-01 11:18:00 | Immunogold staining and electron microscopy of heart vibrosections was performed to localize Kv4.2/Kv4.3 and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) proteins. Patch-Clamp recordings in control conditions and after lipid raft or caveolae disruption show that the CaMKII-Kv4 channel complex must associate in non-caveolar lipid rafts to be functional. | 31935048 |
| 2018-11-03 10:58:00 | Study revealed that ERK5 signaling promotes phosphorylation of Kv4.2 and inhibits the inactivation of the A-type current for the enhancement of membrane excitability in PC12 cells. | 29996472 |
| 2017-12-23 10:10:00 | Results showed: (i) seizures are associated with more brain damage and neuronal damage is not the major contributor of seizure generation in ischemic rats; (ii) the expression of IA channel subunit Kv4.2 is selectively reduced in ischemic rats with spontaneous behavioral seizures; (iii) The reduction of Kv4.2 may be associated with the long-term increased seizure susceptibility of ischemic rats. | 27259067 |
| 2017-08-19 12:55:00 | NMDA reduced both currents in a concentration-dependent manner, whereas there was no significant impact on the currents when perfused with MK-801. MDD rats exhibited significantly more fibrosis areas in heart tissue and reduced expression of Kv4.2, Kv4.3, and Cav1.2. | 28566490 |
| Type | IDs |
|---|---|
| Synonymous | Kv4.2, RK5, Shal1 |
| Gene |
UniProtKB-ID:
KCND2_RAT
UniprotKB:
Q63881
UniParc:
UPI00000E6E7E
EMBL:
M59980,
S64320
KO:
rno:65180
|
| Nucleutide sequences |
EMBL-CDS:
AAA40929.1,
AAB19939.1
|
| Protein sequencees |
RefSeq:
NP_113918.2
|
| Others |
UniRef100:
UniRef100_Q63881
UniRef90:
UniRef90_Q63881
UniRef50:
UniRef50_Q63881
UniGene:
Rn.87841
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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