| Type | Description |
|---|---|
| Definition | UPF3A regulator of nonsense mediated mRNA decay |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:35:00 | (Phospho)proteomic Profiling of Microsatellite Unstable CRC Cells Reveals Alterations in Nuclear Signaling and Cholesterol Metabolism Caused by Frameshift Mutation of NMD Regulator UPF3A. | 32718059 |
| 2020-02-22 12:08:00 | Study observed that CHERP and its binding partner SR140 are significantly upregulated in human clinical colorectal cancer tissues (CRC) and clarified how CHERP/SR140 exert an oncogenic role in CRC development partially through regulating expression of UPF3A variants. | 30977118 |
| 2010-01-21 00:00:00 | hUpf3a is much less active than hUpf3b to induce NMD and to stimulate translation | 16601204 |
| 2010-01-21 00:00:00 | Results suggest that UPF3A levels are tightly regulated by a post-transcriptional switch to maintain appropriate levels of NMD substrates in cells containing different levels of UPF3B. | 19503078 |
| 2010-01-21 00:00:00 | The Upf complex communicates with the exon-junction complex and triggers nonsense-mediated decay in the cytoplasm. | 17803942 |
| Type | IDs |
|---|---|
| Synonymous | HUPF3A, RENT3A, UPF3 |
| Gene |
UniProtKB-ID:
REN3A_HUMAN,
B3KUE7_HUMAN
UniprotKB:
Q9H1J1,
B3KUE7
UniParc:
UPI000000D939,
UPI0000072FCB,
UPI00003D089F,
UPI00001A3E56
EMBL:
AF318575,
AL160396,
CH471085,
AY013250,
BC008694,
AK097027,
BC023569
Ensembl:
ENSG00000169062
KO:
hsa:65110
|
| Nucleutide sequences |
EMBL-CDS:
AAG60690.1,
AAG48510.1,
AAH08694.1,
EAX09252.1,
AAH23569.1,
EAX09247.1,
BAG53409.1,
EAX09251.1
Gene_ORFName:
hCG_2011952
Ensembl_TRS:
ENST00000351487,
ENST00000375299
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000364448,
ENSP00000329592
RefSeq:
NP_075387.1,
NP_001340574.1,
NP_001340576.1,
XP_011533150.1,
XP_024305171.1,
NP_542418.1,
XP_011533147.1,
NP_001340575.1,
NP_001340580.1,
XP_016876198.1,
NP_001340581.1,
NP_001340579.1,
XP_016876200.1,
XP_005266259.1,
XP_024305170.1,
NP_001340578.1,
NP_001340573.1,
XP_024305169.1,
XP_011533149.1,
NP_001340577.1,
XP_011533146.1,
XP_024305168.1,
XP_011533148.1,
XP_006720054.1
|
| Others |
UniRef100:
UniRef100_Q9H1J1
UniRef90:
UniRef90_Q9H1J1
UniRef50:
UniRef50_Q9H1J1
UniGene:
Hs.533855
CCDS:
CCDS9544.1,
CCDS9543.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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