| Type | Description |
|---|---|
| Definition | interleukin-1 receptor-associated kinase 1 binding protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2013-11-16 10:28:00 | SIMPL functions as a TNFalpha-dependent p65 co-activator by facilitating the recruitment of MED1 to p65 containing transcriptional complexes to control the expression of a subset of TNFalpha-induced genes. | 23630580 |
| 2010-07-26 11:45:00 | IRAK1BP1 functions through its effects on NF-kappaB as a molecular switch to bias innate immune pathways toward the resolution of inflammation | 20534545 |
| 2010-03-01 11:59:00 | Signals transduced through the tumor necrosis factor-alpha-tumor necrosis factor -receptor I-SIMPL(substrate that interacts with mouse pelle-like kinase) pathway support hematopoietic progenitor cell survival, growth and differentiation | 19941935 |
| 2010-01-21 00:00:00 | Hsp70/Hsc70 bind the intrinsically disordered amino-terminal region of SIMPL to stabilize the protein and thereby regulate its activity. | 17233114 |
| 2010-01-21 00:00:00 | TNF-alpha activation of NF-kappaB dependent-gene expression requires nuclear relocalization of p65 as well as nuclear relocalization of SIMPL, generating a TNF-alpha-specific induction of gene expression. | 15485901 |
| Type | IDs |
|---|---|
| Synonymous | 4921528N06Rik, AI851240, Aabp3, Aip70, Simpl |
| Gene |
UniProtKB-ID:
IKBP1_MOUSE,
G5E885_MOUSE
UniprotKB:
Q9ESJ7,
G5E885
UniParc:
UPI0000023A08,
UPI00001932D5
EMBL:
AC151966,
AC132323,
AK045436,
BC061099,
AK020448,
AK009948,
AK076594,
AK013036,
AK020170,
AJ242722,
AF093135
Ensembl:
ENSMUSG00000032251
KO:
mmu:65099
|
| Nucleutide sequences |
EMBL-CDS:
BAC36407.1,
CAB92240.1,
BAC32366.1,
BAC25386.1,
BAB32019.1,
AAH61099.1,
AAG16774.1,
BAB32106.2,
BAB26602.1
Ensembl_TRS:
ENSMUST00000113245,
ENSMUST00000034783
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000108871,
ENSMUSP00000034783
RefSeq:
NP_075362.3,
NP_001161712.1
|
| Others |
UniRef100:
UniRef100_Q9ESJ7,
UniRef100_G5E885
UniRef90:
UniRef90_Q9ESJ7,
UniRef90_G5E885
UniRef50:
UniRef50_Q9ESJ7
UniGene:
Mm.41415
CCDS:
CCDS23372.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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