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6503 SLA

6503

SLA

Src like adaptor

protein-coding

Homo sapiens

基因描述

Type Description
Definition Src like adaptor

研究结论

Date Results Publications
2020-09-12 15:58:00 SLAP Is a Negative Regulator of FcepsilonRI Receptor-Mediated Signaling and Allergic Response. 31156621
2015-08-22 10:47:00 results suggest that cytoplasm-specific transduction of the SH3 and SH2 domains of SLAP has a therapeutic potential of being an immunosuppressive reagent for the treatment of various autoimmune diseases 25800872
2014-09-20 11:30:00 Taken together the data demonstrate that SLAP negatively regulates wild-type c-Kit signaling, but not its oncogenic counterpart, indicating a possible mechanism by which the oncogenic c-Kit bypasses the normal cellular negative feedback control 24284075
2013-06-29 11:21:00 upon ligand stimulation SLAP stably associates with Flt3 through multiple phosphotyrosine residues in Flt3. SLAP mRNA is differentially expressed in different cancers and its expression significantly increased in patients carrying the Flt3-ITD mutation 23300935
2012-10-20 10:20:00 These data provide evidence for src-like adaptor protein-dependent regulation of CD3 zeta-chain in the fine control of TCR signaling. 22798681

名称对应

Type IDs
Synonymous SLA1, SLAP
Gene
UniProtKB-ID: SLAP1_HUMAN
UniprotKB: Q13239
UniParc: UPI0000210625, UPI0000210623, UPI000004B144, UPI0001914ED2, UPI0001914E74
EMBL: CR536537, CH471060, U30473, AJ238591, AF305872, BC007042, AK312584, AK297423, AK297519, U44403, AF235100, D89077
Ensembl: ENSG00000155926
KO: hsa:6503
Nucleutide sequences
EMBL-CDS: BAA13758.1, AAC50357.1, AAC27662.1, CAG38774.1, AAH07042.1, EAW92159.1, BAG35478.1, BAH12602.1, BAH12578.1, CAB53536.1
Ensembl_TRS: ENST00000338087, ENST00000517648, ENST00000395352, ENST00000427060, ENST00000524345
Protein sequencees
Ensembl_PRO: ENSP00000378759, ENSP00000337548, ENSP00000394049, ENSP00000428559, ENSP00000427928
RefSeq: NP_006739.2, XP_016869228.1, NP_001269894.1, NP_001039022.2, NP_001269893.1, NP_001039021.1
Others
UniRef100: UniRef100_Q13239
UniRef90: UniRef90_Q13239
UniRef50: UniRef50_Q13239
UniGene: Hs.75367
CCDS: CCDS64977.1, CCDS47923.1, CCDS47922.1, CCDS6370.1, CCDS64978.1

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