| Type | Description |
|---|---|
| Definition | SIX homeobox 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:24:00 | The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically. | 32051553 |
| 2020-09-26 13:07:00 | Upregulation of sine oculis homeobox homolog 3 is associated with proliferation, invasion, migration, as well as poor prognosis of esophageal cancer. | 30672777 |
| 2019-01-19 12:07:00 | The authors demonstrate that the SIX3/LSD1/NuRD(MTA3) complex inhibits carcinogenesis in breast cancer cells and suppresses metastasis in breast cancer. | 29463994 |
| 2018-09-01 10:31:00 | SIX3 deletions and incomplete penetrance in families affected by holoprosencephaly have been described. | 28670735 |
| 2018-04-21 12:10:00 | Results demonstrate that Six3 silence or loss in glioma is induced by its promoter hypermethylation and Six3 down-regulation contributes to proliferation and invasion of glioma. And this process is involved in activation of Wnt/beta-catenin pathway. Six3 play a suppressor role in the initiation and progression of human glioma and potentially serve as a target for the diagnosis and treatment of human glioma. | 28643150 |
| Type | IDs |
|---|---|
| Synonymous | HPE2 |
| Gene |
UniProtKB-ID:
SIX3_HUMAN
UniprotKB:
O95343
UniParc:
UPI00001359C4
EMBL:
AC012354,
AF092047,
AJ012611,
AF083891,
CH471053,
AF049339
Ensembl:
ENSG00000138083
KO:
hsa:6496
|
| Nucleutide sequences |
EMBL-CDS:
EAX00268.1,
AAD51091.1,
AAD11939.1,
EAX00267.1,
AAD15753.1,
CAB42539.1,
AAX93283.1
Ensembl_TRS:
ENST00000260653
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000260653
RefSeq:
NP_005404.1
|
| Others |
UniRef100:
UniRef100_O95343
UniRef90:
UniRef90_O95343
UniRef50:
UniRef50_Q62233
UniGene:
Hs.567336
CCDS:
CCDS1821.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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