| Type | Description |
|---|---|
| Definition | SIM bHLH transcription factor 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 12:58:00 | CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer. | 32124945 |
| 2020-05-23 13:20:00 | these results show a role for SIM2s in the resolution of replication stress and further characterize the necessity of SIM2s for effective RAD51 loading in response to DNA damage or stress, ultimately promoting genomic integrity and thus preventing the accumulation of cancer-promoting mutations. | 31775907 |
| 2020-05-23 10:15:00 | These findings support a role for SIM2s in the prevention of breast cancer progression through its ability to repress PTGS2 expression via modulating the NFkappaB signaling pathway. | 31783895 |
| 2019-08-10 10:39:00 | attenuates resistance to hypoxia and tumor growth by transcriptional suppression of HIF1A in uterine cervical squamous cell carcinoma | 29109451 |
| 2019-05-04 10:05:00 | SIM2s interacts with ATM and is stabilized through ATM-dependent phosphorylation in response to IR. | 30531838 |
| Type | IDs |
|---|---|
| Synonymous | HMC13F06, HMC29C01, SIM, bHLHe15 |
| Gene |
UniProtKB-ID:
SIM2_HUMAN
UniprotKB:
Q14190
UniParc:
UPI000013599A,
UPI0000206E54
EMBL:
CH471079,
AP000697,
U80456,
D70838,
D85922,
D44445,
D44446,
D44444,
BC110444,
D44447,
AB003185,
AP001726,
AJ001858,
D44448,
U80457,
X84790
Ensembl:
ENSG00000159263
KO:
hsa:6493
|
| Nucleutide sequences |
EMBL-CDS:
AAB62396.1,
BAA07908.1,
CAA59261.1,
BAA11108.1,
BAA89433.1,
BAA21490.1,
AAB62397.1,
BAA07909.1,
AAI10445.1,
BAA07906.1,
EAX09737.1,
BAA07907.1,
BAA12919.1,
CAA05055.1,
BAA07910.1,
BAA21489.1
Ensembl_TRS:
ENST00000290399
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000290399
RefSeq:
NP_033664.2,
NP_005060.1,
XP_011527996.1,
XP_016883931.1
|
| Others |
UniRef100:
UniRef100_Q14190
UniRef90:
UniRef90_Q14190
UniRef50:
UniRef50_Q14190
UniGene:
Hs.146186
CCDS:
CCDS13646.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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