| Type | Description |
|---|---|
| Definition | SIM bHLH transcription factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-12-22 10:43:00 | SIM1 is part of the leptin-melanocortin system. | 30297428 |
| 2018-07-21 12:02:00 | SIM1 was highly methylated in the majority of the cervical cancer tissues. Hypermethylation of SIM1 led to a pronounced reduction in SIM1 expression in cervical cancer tissues compared with normal cervix. The degree of SIM1 methylation was significantly associated with the severity of the disease. | 29063719 |
| 2018-03-31 10:25:00 | Single nucleotide polymorphism rs3734354 in SIM1 gene is associated with severe early-onset obesity. | 28593922 |
| 2017-09-16 13:09:00 | identified a novel SIM1 variant, p.D134N, in 4 obese individuals from a single pedigree which is also associated with lower preference for certain foods | 28472148 |
| 2016-12-17 11:37:00 | no gene harboring deletions were identified in the SIM1 and MRAP2 regions in the Prader Willi like (PWL) cohort; further functional analysis of p.P352S found in SIM1 and p.A40S found in MRAP2 is useful; this would provide further support for possible role of SIM1 and MRAP2 in the pathogenesis of the PWL phenotype in a limited number of patients | 26795956 |
| Type | IDs |
|---|---|
| Synonymous | bHLHe14 |
| Gene |
UniProtKB-ID:
SIM1_HUMAN
UniprotKB:
P81133
UniParc:
UPI000013D355
EMBL:
AL121948,
U70212,
Z86062
Ensembl:
ENSG00000112246
KO:
hsa:6492
|
| Nucleutide sequences |
EMBL-CDS:
AAB62395.1
Ensembl_TRS:
ENST00000262901,
ENST00000369208
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000262901,
ENSP00000358210
RefSeq:
XP_011534374.1,
NP_001361698.1,
NP_005059.2
|
| Others |
UniRef100:
UniRef100_P81133
UniRef90:
UniRef90_P81133
UniRef50:
UniRef50_Q98SJ5
UniGene:
Hs.520293
CCDS:
CCDS5045.1
|