| Type | Description |
|---|---|
| Definition | alanine--glyoxylate aminotransferase 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-28 12:12:00 | Alanine-Glyoxylate Aminotransferase 2 (AGTX2)-dependent pathway is a relatively recently discovered alternative pathway of dimethylarginine catabolism and its role on Rheumatoid Arthritis -related atherosclerotic disease is yet to be established. Gene variants of AGTX-2 may influence dimethylarginine levels in Rheumatoid Arthritis patients and provide the rationale for larger studies in this field. | 31062169 |
| 2019-04-27 11:59:00 | Carriers of AGXT2 rs37369-T allele (CT + TT genotypes) and AGXT2 rs16899974-A allele (CA + AA genotypes) had 2.4- and 2.08-fold higher risk of having coronary artery disease than CC genotype in both SNPs (p = 0.0050 and 0.0192, respectively). AGXT2 rs37369 TT and AGXT2 rs16899974 AA genotypes were associated with the highest serum ADMA and SDMA | 30284143 |
| 2018-05-12 11:58:00 | We purified human AGXT2 from tissues of AGXT2 transgenic mice and demonstrated its ability to metabolize homoarginine to 6-guanidino-2-oxocaproic acid (GOCA). After incubation of HepG2 cells overexpressing AGXT2 with isotope-labeled homoarginine-d4 we were able to detect labeled GOCA in the medium | 27752063 |
| 2018-02-24 11:50:00 | study in a well-characterized rheumatoid arthritis population did not show an association between serum concentrations of dimethylarginines and genetic variants of the AGXT2 gene. | 28357606 |
| 2017-12-30 10:42:00 | AGXT2 rs37369 polymorphism is associated with increased risk for chronic heart failure, which may due to distinct disparities of alleles in asymmetric dimethylarginine degradation | 27423328 |
| Type | IDs |
|---|---|
| Synonymous | AGT2, BAIBA, DAIBAT |
| Gene |
UniProtKB-ID:
AGT2_HUMAN
UniprotKB:
Q9BYV1
UniParc:
UPI0001D3B154,
UPI0000125709
EMBL:
AJ292204,
AB193309,
AK223375,
BC150603,
AK223144,
AC010368,
AK223128,
BC144268
Ensembl:
ENSG00000113492
KO:
hsa:64902
|
| Nucleutide sequences |
EMBL-CDS:
AAI44269.1,
CAC24841.1,
AAI50604.1,
BAD96848.1,
BAD97095.1,
BAD66662.1
Ensembl_TRS:
ENST00000618015,
ENST00000231420,
ENST00000510428
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000422799,
ENSP00000479154,
ENSP00000231420
RefSeq:
XP_005248395.1,
XP_016865237.1,
NP_001293102.1,
NP_114106.1,
XP_005248394.1
|
| Others |
UniRef100:
UniRef100_Q9BYV1
UniRef90:
UniRef90_Q9BYV1
UniRef50:
UniRef50_Q9BYV1
UniGene:
Hs.34494
CCDS:
CCDS78000.1,
CCDS3908.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员