| Type | Description |
|---|---|
| Definition | methyltransferase like 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:20:00 | METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing. | 32813009 |
| 2020-08-29 12:47:00 | N(6)-Deoxyadenosine Methylation in Mammalian | 32183942 |
| 2020-08-28 13:23:00 | METTL4 methylates U2 snRNA Am at position 30 to generate m6Am in vivo. 'HMAGKD', where H = A/C/U, M = A/C, K = G/U, D = A/G/U, and A is the methylation site, is METTL4's in vivo preferred target motif. | 32813009 |
| 2017-08-26 12:16:00 | For the methylation of adenosine in RNA, Mettl3 is the catalytically active subunit, while Mettl14 plays a structural role critical for substrate recognition. | 27373337 |
| 2014-03-01 12:15:00 | associations revealed between genetic polymorphisms located in the flanking region of the ARID1B genes and hypoesthesia | 23834954 |
| Type | IDs |
|---|---|
| Synonymous | HsT661 |
| Gene |
UniProtKB-ID:
METL4_HUMAN,
J3KNJ7_HUMAN
UniprotKB:
Q8N3J2,
J3KNJ7
UniParc:
UPI00025A2C01,
UPI000020191B
EMBL:
BC111020,
AP005136,
BC136766,
AK026670,
BC136767,
CH471113,
AL834296
Ensembl:
ENSG00000101574
KO:
hsa:64863
|
| Nucleutide sequences |
EMBL-CDS:
AAI36767.1,
EAX01698.1,
AAI36768.1,
BAB15520.1,
CAD38969.1,
AAI11021.1
Ensembl_TRS:
ENST00000574538,
ENST00000319888
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000458290,
ENSP00000320349
RefSeq:
NP_073751.3,
XP_005258189.1,
NP_001295330.1,
XP_011524032.1,
XP_005258190.1
|
| Others |
UniRef100:
UniRef100_J3KNJ7,
UniRef100_Q8N3J2
UniRef90:
UniRef90_Q8N3J2,
UniRef90_A0A2K5WS27
UniRef50:
UniRef50_Q8N3J2
UniGene:
Hs.126888
CCDS:
CCDS11826.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32813009 |
METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing. Nucleic Acids Res Yeek Teck Goh , Casslynn W Q Koh , Donald Yuhui Sim , Xavier Roca , W S Sho Goh |
2020-09-18 | - |
| 31913360 |
METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing. Cell Res Hao Chen , Lei Gu , Esteban A Orellana , Yuanyuan Wang , Jiaojiao Guo , Qi Liu , Longfei Wang , Zhangfei Shen , Hao Wu , Richard I Gregory , Yi Xing , Yang Shi |
2020-06-01 | - |
| 32183942 |
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA. Mol Cell Ziyang Hao , Tong Wu , Xiaolong Cui , Pingping Zhu , Caiping Tan , Xiaoyang Dou , Kai-Wen Hsu , Yueh-Te Lin , Pei-Hua Peng , Li-Sheng Zhang , Yawei Gao , Lulu Hu , Hui-Lung Sun , Allen Zhu , Jianzhao Liu , Kou-Juey Wu , Chuan He |
2020-05-07 | - |
| 30982744 |
An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing. Mol. Cell Soo-Mi Kweon , Yibu Chen , Eugene Moon , Kotryna KvederaviciutÄ , Saulius Klimasauskas , Douglas E Feldman |
2019-06-20 | - |
| 27373337 |
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. Mol. Cell Ping Wang , Katelyn A Doxtader , Yunsun Nam |
2016-07-21 | - |
| 25130324 |
Genes Brain Behav. D-C Cai , H Fonteijn , T Guadalupe , M Zwiers , K Wittfeld , A Teumer , M Hoogman , A Arias-Vásquez , Y Yang , J Buitelaar , G Fernández , H G Brunner , H van Bokhoven , B Franke , K Hegenscheid , G Homuth , S E Fisher , H J Grabe , C Francks , P Hagoort |
2014-09-01 |
MIR4490,
STEAP2-AS1,
LOC101928599,
DISC1FP1,
LOC101929633,
ACAA2,
KLF12,
SLITRK1,
MED12L,
ARAP2,
TMEM18,
DCBLD2,
GCNT7,
SLC38A11,
DTNB,
FAM209A,
ZNF804B,
FBN2,
SMIM13,
FDFT1,
COBLL1,
PCNX1,
VPS8,
IL17RA,
TNFAIP8,
CECR6,
DSE,
FAM209B,
DPY19L2P4,
NDUFA4,
RTFDC1,
DDIT4,
POU3F4,
BNC2,
PRKCA,
METTL4,
KALRN,
KNSTRN,
CCDC149,
MYOM2,
CD28,
SH3BP5,
P2RY14
|
| 23834954 |
Mol Pain Daisuke Kobayashi , Daisuke Nishizawa , Yoshito Takasaki , Shinya Kasai , Takashi Kakizawa , Kazutaka Ikeda , Ken-ichi Fukuda |
2013-07-08 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 16341674 |
Transcriptome analysis of human gastric cancer. Mamm. Genome Jung-Hwa Oh , Jin Ok Yang , Yoonsoo Hahn , Mi-Rang Kim , Sang-Soon Byun , Yeo-Jin Jeon , Jeong-Min Kim , Kyu-Sang Song , Seung-Moo Noh , Sangsoo Kim , Hyang-Sook Yoo , Yong Sung Kim , Nam-Soon Kim |
2005-12-01 |
KCNE3,
SNHG8,
FAM86JP,
RBPMS-AS1,
GATA6-AS1,
TAT-AS1,
PMS2P9,
TOMM6,
LOC100289561,
GCSHP5,
CHAF1A,
THAP9-AS1,
SNHG18,
CEBPZOS,
LINC01006,
LOC100506860,
NRSN2-AS1,
NR1H3,
LINC00659,
SCAMP3,
IL18BP,
ZRANB2-AS2,
RBMS3-AS3,
LOC100996437,
TSPAN1,
FARP1,
STAG3L5P,
GATA2-AS1,
UBR5-AS1,
LINC01273,
LOC101927630,
LINC01479,
LOC101928464,
MIR762HG,
LOC101928738,
DDX39A,
LRRC23,
LCMT1-AS1,
TFG,
WARS2,
NPM3,
CITED2,
TMEM147,
GPNMB,
PFDN6,
UBE2E3,
NXF1,
SEC23B,
CAP1,
PITRM1,
SNHG25,
AGPAT1,
CCT4,
DNPH1,
P3H4,
TRIM3,
POLR3G,
CELF1,
LOC106660606,
CGREF1,
GIPC1,
RPP40,
FRS3,
CPSF4,
FASTK,
EBNA1BP2,
ADIRF,
ADAP1,
UBE2C,
CYB561D2,
TRIM31,
KRR1,
DMC1,
SOX21,
CHI3L2,
ANXA10,
CHEK2,
KLK8,
DUSP10,
CHML,
RPL35,
SEC63,
MAN1B1,
CHP1,
NRM,
GLMP,
RPUSD1,
ECD,
CHRNA5,
WBSCR22,
PTPMT1,
DIS3L,
TSEN15,
MRPL54,
AGAP1,
THEM4,
UBE2J2,
CHCHD1,
ANKRD22
|
| 15489334 |
Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team |
2004-10-01 |
Ldlrap1,
Dnajc3,
Rnaset2a,
Btnl1,
Isg15,
Cyp3a41b,
Ly6c2,
Ccl21b,
Eif3j2,
Mup18,
Lrrc19,
Rcc1,
1700047I17Rik2,
Pcsk9,
Adat3,
Tdrd7,
Sco2,
Gpr153,
Pafah2,
Gm44504,
H6pd,
Adprhl2,
Gpn2,
Rusc2,
Stx12,
Ppp1r8,
Smpdl3b,
Fam46b,
Bsdc1,
Slc44a1,
Zfand2a,
Rubcn,
Kifc1,
Pifo,
C030017K20Rik,
Cbarp,
Rpl5,
Micalcl,
Atg14,
Lrrc8c,
Noc4l,
Nsun5,
Psph,
Trrap,
Mapre3,
Ube3c,
Tbc1d14,
Hscb,
Tyw1,
Emilin1,
Rab28,
Pot1a,
Parp11,
Tada3,
Tra2a,
Brk1,
Fbxl14,
Phrf1,
Plekha1,
Gm21975,
Ric8a,
Mob2,
Prkd2,
Ccp110,
Vrk3,
Grwd1,
Nlrp6,
Trim68,
Psip1,
Spred3,
Faap24,
Ints4,
Rrp8,
Unc45a,
Igflr1,
Sf3b3,
D8Ertd738e,
Usb1,
Champ1,
Smim19,
Exoc8,
Gadd45gip1,
Phkb,
Dohh,
Fam192a,
Enkd1,
Taf5l,
Zdhhc7,
Snapc2,
Ak6,
Gpat4,
Dcun1d2,
Ankrd10,
Cog4,
Hinfp,
Lars2,
Xylb,
Imp3,
Cmtm7
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
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|---|---|---|
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