| Type | Description |
|---|---|
| Definition | DEP domain containing MTOR interacting protein |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:23:00 | DEPTOR is a microRNA-155 target regulating migration and cytokine production in diffuse large B-cell lymphoma cells. | 32702393 |
| 2020-11-28 13:10:00 | DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals. | 31685947 |
| 2020-06-13 10:25:00 | Mechanistically, DEPTOR inhibited both mTOR Complex 1 (mTORC1) and 2 (mTORC2) activities in PA cells. In addition, DEPTOR expression level was increased to suppress mTOR kinase activity via decreasing E3 ubiquitin ligase, betaTrCP1, in response to CAB. | 31176743 |
| 2020-05-23 11:38:00 | We identified and replicated three new genome-wide significant signals of association with idiopathic pulmonary fibrosissusceptibility (associated with altered gene expression of KIF15, MAD1L1, and DEPTOR). The observation that decreased DEPTOR expression associates with increased susceptibility to IPF supports recent studies demonstrating the importance of mTOR signaling in lung fibrosis. | 31710517 |
| 2020-05-09 13:52:00 | The role of DEPTOR polymorphism in T2D vascular complication. | 31453770 |
| Type | IDs |
|---|---|
| Synonymous | DEP.6, DEPDC6 |
| Gene |
UniProtKB-ID:
DPTOR_HUMAN
UniprotKB:
Q8TB45
UniParc:
UPI000013DE38,
UPI0001E8F78E
EMBL:
AP005717,
AK315175,
AK022490,
BC012040,
BC024746,
CH471060,
AL136678,
AK023916,
AC091563,
AK297822
Ensembl:
ENSG00000155792
KO:
hsa:64798
|
| Nucleutide sequences |
EMBL-CDS:
BAG60159.1,
CAB66613.1,
BAG37616.1,
AAH12040.1,
BAB14723.1,
AAH24746.1,
BAB14054.1,
EAW91997.1
Ensembl_TRS:
ENST00000523492,
ENST00000286234
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000286234,
ENSP00000430457
RefSeq:
NP_001269941.1,
NP_073620.2
|
| Others |
UniRef100:
UniRef100_Q8TB45
UniRef90:
UniRef90_Q8TB45
UniRef50:
UniRef50_Q8TB45
UniGene:
Hs.112981
CCDS:
CCDS64960.1,
CCDS6331.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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