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6457 SH3GL3

6457

SH3GL3

SH3 domain containing GRB2 like 3, endophilin A3

protein-coding

Homo sapiens

基因描述

Type Description
Definition SH3 domain containing GRB2 like 3, endophilin A3

研究结论

Date Results Publications
2021-04-17 13:14:00 SH3GL3 functions as a potent tumor suppressor in lung cancer in a SH3 domain dependent manner. 33168185
2020-07-18 10:25:00 Endophilin-A3 functionally associates with CD166-containing early endocytic carriers and physically interacts with the cargo. Study provides strong evidence that the construction of endocytic sites from which CD166 is taken up in an endophilin-A3-dependent manner is driven by extracellular galectin-8, revealing the existence of a previously uncharacterized clathrin-independent endocytic modality in cancer cells. 32193381
2018-03-03 11:45:00 Our findings indicate that SH3GL3 plays an important role in myeloma cell migration/invasion, stemness and chemo-resistance. The SH3GL3-mediated myeloma cell migration/invasion is mediated by FAK/PI3K signaling pathway. 27683032
2013-01-26 11:44:00 Aberrant DNA methylation of SH3GL3 gene is associated with colorectal cancer. 22901147
2012-06-30 11:53:00 SH3GL3 as a novel glioma invasion-associated candidate gene that likely contribute to the invasive phenotype of malignant gliomas. 21722156

名称对应

Type IDs
Synonymous CNSA3, EEN-B2, HsT19371, SH3D2C, SH3P13
Gene
UniProtKB-ID: SH3G3_HUMAN, A0A024R215_HUMAN
UniprotKB: Q99963, A0A024R215
UniParc: UPI0000135935, UPI000002B390, UPI000002B391, UPI000002B392
EMBL: X99664, AF036271, CH471188, AF036270, AF036269, AF036272
Ensembl: ENSG00000140600
KO: hsa:6457
Nucleutide sequences
EMBL-CDS: AAC04766.1, CAA67978.1, AAC04765.1, AAC04767.1, AAC04768.1, EAW62420.1, EAW62421.1
Gene_ORFName: hCG_26601
Ensembl_TRS: ENST00000427482, ENST00000324537
Protein sequencees
Ensembl_PRO: ENSP00000320092, ENSP00000391372
RefSeq: NP_001288038.1, NP_001288037.1, NP_001311114.1, XP_011520194.1, XP_016877975.1, NP_001311113.1, XP_024305785.1, NP_001311112.1, XP_011520191.1, NP_003018.3, XP_011520193.1, NP_001311115.1, NP_001311116.1, NP_001311111.1
Others
UniRef100: UniRef100_Q99963, UniRef100_A0A024R215
UniRef90: UniRef90_G1RIU0, UniRef90_Q99963
UniRef50: UniRef50_G1RIU0, UniRef50_Q99963
UniGene: Hs.270055, Hs.666365
CCDS: CCDS73772.1, CCDS10325.2

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