Akap6 - A-kinase anchoring protein 6-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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64553 Akap6

基因描述

Type	Description
Definition	A-kinase anchoring protein 6

研究结论

Date	Results	Publications
2019-11-16 10:45:00	In cardiac myocytes, PDE4 insulates a mAKAPbeta-targeted pool at the nuclear envelope that prevents nuclear duanyu1529 activation upon beta2-AR stimulation.	29733383
2019-06-29 10:38:00	mAKAPbeta signalosomes serve to bidirectionally regulate the nuclear-cytoplasmic localization of class IIa HDACs.[	29522762
2019-05-04 12:59:00	these results highlight the importance of mAKAPbeta signalosomes for regulating MEF2D activity in striated muscle, affirming mAKAPbeta as a nodal regulator in the myocyte intracellular signaling network.	30523159
2016-10-22 10:20:00	These results identify mAKAPalpha as a scaffold for signaling in the stressed neuron that is required for RGC neuroprotection after optic nerve injury.	26844267
2016-03-05 10:21:00	This study show genome-wide significant SNP-based associations within three genomic regions 6q16.1 (MIR2113), 14q12 (AKAP6/NPAS3 region) and 19q13.32 (TOMM40/APOE region) with cognition.	25644384

名称对应

Type	IDs
Synonymous	mAkap
Gene	UniProtKB-ID: AKAP6_RAT, G3V6M0_RAT UniprotKB: Q9WVC7, G3V6M0 UniParc: UPI000019B860, UPI000012575B EMBL: AABR07064294, AABR07064291, AABR07064290, CH473947, AABR07064292, AABR07064293, AF139518 Ensembl: ENSRNOG00000004841 KO: rno:64553
Nucleutide sequences	EMBL-CDS: AAD39150.1, EDM03393.1 Gene_ORFName: rCG_61453 Ensembl_TRS: ENSRNOT00000006562
Protein sequencees	Ensembl_PRO: ENSRNOP00000006562 RefSeq: XP_017449834.1, NP_072140.2, XP_017449832.1, XP_017449833.1, XP_017449835.1, XP_017449831.1, XP_017449836.1
Others	UniRef100: UniRef100_Q9WVC7, UniRef100_G3V6M0 UniRef90: UniRef90_Q9WVC7 UniRef50: UniRef50_Q9WVC7 UniGene: Rn.147642

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
30523159	Muscle A-kinase-anchoring protein-Î²-bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D. J Biol Chem Jinliang Li , Shania Aponte Paris , Hrishikesh Thakur , Michael S Kapiloff , Kimberly L Dodge-Kafka	2019-02-15	-
29733383	PDE4 and mAKAPÎ² are nodal organizers of Î²2-ARs nuclear PKA signalling in cardiac myocytes. Cardiovasc. Res. Ibrahim Bedioune , Florence Lefebvre , Patrick LechÃªne , Audrey Varin , ValÃ©rie Domergue , Michael S Kapiloff , Rodolphe Fischmeister , GrÃ©goire Vandecasteele	2018-09-01	-
29522762	Bidirectional regulation of HDAC5 by mAKAPÎ² signalosomes in cardiac myocytes. J. Mol. Cell. Cardiol. Kimberly L Dodge-Kafka , Moriah Gildart , Jinliang Li , Hrishikesh Thakur , Michael S Kapiloff	2018-05-01	-
29979793	Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility. PLoS One Madalene Earp , Jonathan P Tyrer , Stacey J Winham , Hui-Yi Lin , Ganna Chornokur , Joe Dennis , Katja K H Aben , Hoda Anton-Culver , Natalia Antonenkova , Elisa V Bandera , Yukie T Bean , Matthias W Beckmann , Line Bjorge , Natalia Bogdanova , Louise A Brinton , Angela Brooks-Wilson , Fiona Bruinsma , Clareann H Bunker , Ralf Butzow , Ian G Campbell , Karen Carty , Jenny Chang-Claude , Linda S Cook , Daniel W Cramer , Julie M Cunningham , Cezary Cybulski , Agnieszka Dansonka-Mieszkowska , Evelyn Despierre , Jennifer A Doherty , Thilo DÃ¶rk , Andreas du Bois , Matthias DÃ¼rst , Douglas F Easton , Diana M Eccles , Robert P Edwards , Arif B Ekici , Peter A Fasching , Brooke L Fridley , Aleksandra Gentry-Maharaj , Graham G Giles , Rosalind Glasspool , Marc T Goodman , Jacek Gronwald , Philipp Harter , Alexander Hein , Florian Heitz , Michelle A T Hildebrandt , Peter Hillemanns , Claus K Hogdall , Estrid HÃ¸gdall , Satoyo Hosono , Edwin S Iversen , Anna Jakubowska , Allan Jensen , Bu-Tian Ji , Audrey Y Jung , Beth Y Karlan , Melissa Kellar , Lambertus A Kiemeney , Boon Kiong Lim , Susanne K Kjaer , Camilla Krakstad , Jolanta Kupryjanczyk , Diether Lambrechts , Sandrina Lambrechts , Nhu D Le , Shashi Lele , Jenny Lester , Douglas A Levine , Zheng Li , Dong Liang , Jolanta Lissowska , Karen Lu , Jan Lubinski , Lene Lundvall , Leon F A G Massuger , Keitaro Matsuo , Valerie McGuire , John R McLaughlin , Iain McNeish , Usha Menon , Roger L Milne , Francesmary Modugno , Kirsten B Moysich , Roberta B Ness , Heli Nevanlinna , Kunle Odunsi , Sara H Olson , Irene Orlow , Sandra Orsulic , James Paul , Tanja Pejovic , Liisa M Pelttari , Jenny B Permuth , Malcolm C Pike , Elizabeth M Poole , Barry Rosen , Mary Anne Rossing , Joseph H Rothstein , Ingo B Runnebaum , Iwona K Rzepecka , Eva Schernhammer , Ira Schwaab , Xiao-Ou Shu , Yurii B Shvetsov , Nadeem Siddiqui , Weiva Sieh , Honglin Song , Melissa C Southey , Beata Spiewankiewicz , Lara Sucheston-Campbell , Ingvild L Tangen , Soo-Hwang Teo , Kathryn L Terry , Pamela J Thompson , Lotte Thomsen , Shelley S Tworoger , Anne M van Altena , Ignace Vergote , Liv Cecilie Vestrheim Thomsen , Robert A Vierkant , Christine S Walsh , Shan Wang-Gohrke , Nicolas Wentzensen , Alice S Whittemore , Kristine G Wicklund , Lynne R Wilkens , Yin-Ling Woo , Anna H Wu , Xifeng Wu , Yong-Bing Xiang , Hannah Yang , Wei Zheng , Argyrios Ziogas , Alice W Lee , Celeste L Pearce , Andrew Berchuck , Joellen M Schildkraut , Susan J Ramus , Alvaro N A Monteiro , Steven A Narod , Thomas A Sellers , Simon A Gayther , Linda E Kelemen , Georgia Chenevix-Trench , Harvey A Risch , Paul D P Pharoah , Ellen L Goode , Catherine M Phelan	2018-01-01	-
26891149	Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia. Epigenetics Thomas Wilhelm , Daniel B Lipka , Tania Witte , Justyna A Wierzbinska , Silvia Fluhr , Monika Helf , Oliver MÃ¼cke , Rainer Claus , Carolin Konermann , Peter NÃ¶llke , Charlotte M Niemeyer , Christian Flotho , Christoph Plass	2016-02-01	-
26844267	Muscle A-Kinase Anchoring Protein-Î± is an Injury-Specific Signaling Scaffold Required for Neurotrophic- and Cyclic Adenosine Monophosphate-Mediated Survival. EBioMedicine Yan Wang , Evan G Cameron , Jinliang Li , Travis L Stiles , Michael D Kritzer , Rahul Lodhavia , Jonathan Hertz , Tu Nguyen , Michael S Kapiloff , Jeffrey L Goldberg	2015-12-01	-
25644384	Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Mol Psychiatry G Davies , N Armstrong , J C Bis , J Bressler , V Chouraki , S Giddaluru , E Hofer , C A Ibrahim-Verbaas , M Kirin , J Lahti , S J van der Lee , S Le Hellard , T Liu , R E Marioni , C Oldmeadow , I Postmus , A V Smith , J A Smith , A Thalamuthu , R Thomson , V Vitart , J Wang , L Yu , L Zgaga , W Zhao , R Boxall , S E Harris , W D Hill , D C Liewald , M Luciano , H Adams , D Ames , N Amin , P Amouyel , A A Assareh , R Au , J T Becker , A Beiser , C Berr , L Bertram , E Boerwinkle , B M Buckley , H Campbell , J Corley , P L De Jager , C Dufouil , J G Eriksson , T Espeseth , J D Faul , I Ford , Generation Scotland , R F Gottesman , M E Griswold , V Gudnason , T B Harris , G Heiss , A Hofman , E G Holliday , J Huffman , S L R Kardia , N Kochan , D S Knopman , J B Kwok , J-C Lambert , T Lee , G Li , S-C Li , M Loitfelder , O L Lopez , A J Lundervold , A Lundqvist , K A Mather , S S Mirza , L Nyberg , B A Oostra , A Palotie , G Papenberg , A Pattie , K Petrovic , O Polasek , B M Psaty , P Redmond , S Reppermund , J I Rotter , H Schmidt , M Schuur , P W Schofield , R J Scott , V M Steen , D J Stott , J C van Swieten , K D Taylor , J Trollor , S Trompet , A G Uitterlinden , G Weinstein , E Widen , B G Windham , J W Jukema , A F Wright , M J Wright , Q Yang , H Amieva , J R Attia , D A Bennett , H Brodaty , A J M de Craen , C Hayward , M A Ikram , U Lindenberger , L-G Nilsson , D J Porteous , K RÃ¤ikkÃ¶nen , I Reinvang , I Rudan , P S Sachdev , R Schmidt , P R Schofield , V Srikanth , J M Starr , S T Turner , D R Weir , J F Wilson , C van Duijn , L Launer , A L Fitzpatrick , S Seshadri , T H Mosley , I J Deary	2015-02-01	-
24812305	The scaffold protein muscle A-kinase anchoring protein Î² orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Circ Heart Fail Michael D Kritzer , Jinliang Li , Catherine L Passariello , Marjorie Gayanilo , Hrishikesh Thakur , Joseph Dayan , Kimberly Dodge-Kafka , Michael S Kapiloff	2014-07-01	Nkx2-5, Akap6
23261540	Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes. Exp. Cell Res. Jinliang Li , Maximilian A X Vargas , Michael S Kapiloff , Kimberly L Dodge-Kafka	2013-02-15	Ppp3ca, Akap6, Ppp3ca, Mef2a, Akap6
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-

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