| Type | Description |
|---|---|
| Definition | SH3 domain binding protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-06 10:32:00 | The current study shows that SH3BP2 is expressed in primary tumors and cell lines from Gastrointestinal stromal tumors (GISTs) patients and that SH3BP2 silencing leads to a downregulation of oncogenic KIT and PDGFRA expression and an increase in apoptosis in imatinib-sensitive and imatinib-resistant GIST cells. | 29885053 |
| 2018-09-01 11:09:00 | All members featured a heterozygous missense c.1244G>C; p.Arg415Pro SH3BP2 mutation | 28721660 |
| 2015-07-04 11:00:00 | The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival. | 25810396 |
| 2015-04-11 10:14:00 | A c.1244G>A (p.Arg415Gln) mutation in SH3BP2 gene causes cherubism in a Turkish family | 24608212 |
| 2013-07-20 11:58:00 | Authors conclude that a novel p.Asp419Tyr alteration in SH3BP2 to be a cherubism-causing mutation in a Turkish family. | 23083484 |
| Type | IDs |
|---|---|
| Synonymous | 3BP-2, 3BP2, CRBM, CRPM, RES4-23 |
| Gene |
UniProtKB-ID:
3BP2_HUMAN,
A0A384N6E5_HUMAN
UniprotKB:
P78314,
A0A384N6E5
UniParc:
UPI0000124ED7,
UPI00017A7A9D,
UPI000002A2BE,
UPI00019638E3
EMBL:
AF000936,
GQ900977,
U56386,
CH471131,
AK312286,
AB000463,
AL121750,
BC022996,
AB000462,
AK299996
Ensembl:
ENSG00000087266
KO:
hsa:6452
|
| Nucleutide sequences |
EMBL-CDS:
BAG35213.1,
BAA19120.1,
EAW82509.1,
EAW82512.1,
BAG61816.1,
EAW82511.1,
AAH22996.1,
AAB72034.1,
BAA19119.1,
EAW82510.1,
AAB59973.1,
ADO22494.1
Gene_ORFName:
RES4-23
Ensembl_TRS:
ENST00000503393,
ENST00000511747,
ENST00000356331,
ENST00000515737,
ENST00000435136,
ENST00000513020
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000424072,
ENSP00000348685,
ENSP00000424846,
ENSP00000422168,
ENSP00000403231,
ENSP00000422605
RefSeq:
NP_003014.3,
NP_001139327.1,
NP_001116153.1,
NP_001139328.1
|
| Others |
UniRef100:
UniRef100_P78314
UniRef90:
UniRef90_P78314
UniRef50:
UniRef50_P78314
UniGene:
Hs.167679
CCDS:
CCDS33944.1,
CCDS54716.1,
CCDS54715.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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