| Type | Description |
|---|---|
| Definition | membrane spanning 4-domains A4E |
| Date | Results | Publications |
|---|---|---|
| 2017-09-23 10:45:00 | Addition of the minor allele for rs670139 (MS4A4E), rs9331896 (CLU), and rs12155159 (NME8) was nominally associated with change on the DWRT, and WFT, respectively, in whites. For rs670139 and rs9331896 the association was only significant in individuals bearing at least one APOE 4 allele in stratified analyses. | 27781389 |
| 2016-09-24 10:04:00 | We replicated the rs11136000 (CLU)- rs670139 (MS4A4E) interaction, demonstrated an association in APOE epsilon4 negative subjects, and reported evidence of a possible dominant effect for MS4A4E. | 26449541 |
| 2011-07-02 10:03:00 | ABCA7 and the MS4A6A/MS4A4E gene cluster are new Alzheimer's disease susceptibility loci. | 21460840 |
| 2010-06-30 22:06:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| Type | IDs |
|---|---|
| Gene | |
| Nucleutide sequences | |
| Protein sequencees |
RefSeq:
XP_011543718.1,
XP_011543720.1,
NP_001338164.1,
XP_016874130.1,
XP_011543721.1
|
| Others |
UniGene:
Hs.559934
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 27781389 |
Am J Med Genet B Neuropsychiatr Genet Jan Bressler , Thomas H Mosley , Alan Penman , Rebecca F Gottesman , Beverly Gwen Windham , David S Knopman , Lisa M Wruck , Eric Boerwinkle |
2017-04-01 | - |
| 26449541 |
Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement Mark T W Ebbert , Kevin L Boehme , Mark E Wadsworth , Lyndsay A Staley , Alzheimer's Disease Neuroimaging Initiative , Alzheimer's Disease Genetics Consortium , Shubhabrata Mukherjee , Paul K Crane , Perry G Ridge , John S K Kauwe |
2016-02-01 | - |
| 23954108 |
Population-based analysis of Alzheimer's disease risk alleles implicates genetic interactions. Biol. Psychiatry Mark T W Ebbert , Perry G Ridge , Andrew R Wilson , Aaron R Sharp , Matthew Bailey , Maria C Norton , JoAnn T Tschanz , Ronald G Munger , Christopher D Corcoran , John S K Kauwe |
2014-05-01 | - |
| 23118302 |
Circ Cardiovasc Genet Audrey Y Chu , Franco Guilianini , Harald Grallert , Josée Dupuis , Christie M Ballantyne , Bryan J Barratt , Fredrik Nyberg , Daniel I Chasman , Paul M Ridker |
2012-12-01 |
CETP,
CELSR2,
LPAR3,
GCKR,
C14orf177,
CPEB1-AS1,
APOB,
APOC1,
APOE,
LPA,
RNF213,
SORT1,
MS4A4E,
NOX5,
PLA2G7,
AP3B2,
VMP1,
ABCG2,
SCARB1
|
| 21460840 |
Nat Genet Paul Hollingworth , Denise Harold , Rebecca Sims , Amy Gerrish , Jean-Charles Lambert , Minerva M Carrasquillo , Richard Abraham , Marian L Hamshere , Jaspreet Singh Pahwa , Valentina Moskvina , Kimberley Dowzell , Nicola Jones , Alexandra Stretton , Charlene Thomas , Alex Richards , Dobril Ivanov , Caroline Widdowson , Jade Chapman , Simon Lovestone , John Powell , Petroula Proitsi , Michelle K Lupton , Carol Brayne , David C Rubinsztein , Michael Gill , Brian Lawlor , Aoibhinn Lynch , Kristelle S Brown , Peter A Passmore , David Craig , Bernadette McGuinness , Stephen Todd , Clive Holmes , David Mann , A David Smith , Helen Beaumont , Donald Warden , Gordon Wilcock , Seth Love , Patrick G Kehoe , Nigel M Hooper , Emma R L C Vardy , John Hardy , Simon Mead , Nick C Fox , Martin Rossor , John Collinge , Wolfgang Maier , Frank Jessen , Eckart Rüther , Britta Schürmann , Reiner Heun , Heike Kölsch , Hendrik van den Bussche , Isabella Heuser , Johannes Kornhuber , Jens Wiltfang , Martin Dichgans , Lutz Frölich , Harald Hampel , John Gallacher , Michael Hüll , Dan Rujescu , Ina Giegling , Alison M Goate , John S K Kauwe , Carlos Cruchaga , Petra Nowotny , John C Morris , Kevin Mayo , Kristel Sleegers , Karolien Bettens , Sebastiaan Engelborghs , Peter P De Deyn , Christine Van Broeckhoven , Gill Livingston , Nicholas J Bass , Hugh Gurling , Andrew McQuillin , Rhian Gwilliam , Panagiotis Deloukas , Ammar Al-Chalabi , Christopher E Shaw , Magda Tsolaki , Andrew B Singleton , Rita Guerreiro , Thomas W Mühleisen , Markus M Nöthen , Susanne Moebus , Karl-Heinz Jöckel , Norman Klopp , H-Erich Wichmann , V Shane Pankratz , Sigrid B Sando , Jan O Aasly , Maria Barcikowska , Zbigniew K Wszolek , Dennis W Dickson , Neill R Graff-Radford , Ronald C Petersen , Alzheimer's Disease Neuroimaging Initiative , Cornelia M van Duijn , Monique M B Breteler , M Arfan Ikram , Anita L DeStefano , Annette L Fitzpatrick , Oscar Lopez , Lenore J Launer , Sudha Seshadri , CHARGE consortium , Claudine Berr , Dominique Campion , Jacques Epelbaum , Jean-François Dartigues , Christophe Tzourio , Annick Alpérovitch , Mark Lathrop , EADI1 consortium , Thomas M Feulner , Patricia Friedrich , Caterina Riehle , Michael Krawczak , Stefan Schreiber , Manuel Mayhaus , S Nicolhaus , Stefan Wagenpfeil , Stacy Steinberg , Hreinn Stefansson , Kari Stefansson , Jon Snaedal , Sigurbjörn Björnsson , Palmi V Jonsson , Vincent Chouraki , Benjamin Genier-Boley , Mikko Hiltunen , Hilkka Soininen , Onofre Combarros , Diana Zelenika , Marc Delepine , Maria J Bullido , Florence Pasquier , Ignacio Mateo , Ana Frank-Garcia , Elisa Porcellini , Olivier Hanon , Eliecer Coto , Victoria Alvarez , Paolo Bosco , Gabriele Siciliano , Michelangelo Mancuso , Francesco Panza , Vincenzo Solfrizzi , Benedetta Nacmias , Sandro Sorbi , Paola Bossù , Paola Piccardi , Beatrice Arosio , Giorgio Annoni , Davide Seripa , Alberto Pilotto , Elio Scarpini , Daniela Galimberti , Alexis Brice , Didier Hannequin , Federico Licastro , Lesley Jones , Peter A Holmans , Thorlakur Jonsson , Matthias Riemenschneider , Kevin Morgan , Steven G Younkin , Michael J Owen , Michael O'Donovan , Philippe Amouyel , Julie Williams |
2011-05-01 | - |
| 20379614 |
Mol. Med. Jed E Rose , Frédérique M Behm , Tomas Drgon , Catherine Johnson , George R Uhl |
2010-03-17 | - |
| 11486273 |
Structural organization of the human MS4A gene cluster on Chromosome 11q12. Immunogenetics Y Liang , T R Buckley , L Tu , S D Langdon , T F Tedder |
2001-07-01 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员