| Type | Description |
|---|---|
| Definition | NFKB inhibitor zeta |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:38:00 | Threonine Phosphorylation of IkappaBzeta Mediates Inhibition of Selective Proinflammatory Target Genes. | 32035922 |
| 2020-08-01 14:31:00 | results define a crucial role for IkappaBzeta in the antipsoriatic effect of secukinumab. Because IkappaBzeta signature genes were regulated already after 4 days of treatment, this strongly indicates that IkappaBzeta plays a crucial role in the antipsoriatic effects mediated by anti-IL-17A treatment. | 31622687 |
| 2020-07-18 12:18:00 | In fibroblasts, IL-17A response depends on CUX1 and IkappaBzeta to engage the NF-kappaB complex to produce chemoattractants for neutrophil and monocyte recruitment. | 32079724 |
| 2020-05-09 13:39:00 | Our study supported a significant effect of a common NFKBIZ polymorphism on the response to adalimumab. This result could help to optimize the prescription of this anti-TNF, but requires confirmation in other cohorts. | 31267486 |
| 2020-04-25 10:12:00 | found that tumour formation was significantly attenuated in Nfkbiz-mutant mice and cell competition was compromised by disruption of NFKBIZ in human colorectal cancer cells | 31853061 |
| Type | IDs |
|---|---|
| Synonymous | IKBZ, INAP, MAIL |
| Gene |
UniProtKB-ID:
IKBZ_HUMAN
UniprotKB:
Q9BYH8
UniParc:
UPI0000074751,
UPI0000141859,
UPI000006FBB1
EMBL:
CH471052,
AB037925,
AK091782,
BC060800,
AF548362,
DQ224339,
AK054787
Ensembl:
ENSG00000144802
KO:
hsa:64332
|
| Nucleutide sequences |
EMBL-CDS:
EAW79772.1,
BAB40337.1,
AAH60800.1,
AAN40698.1,
BAC03746.1,
BAG51424.1,
ABB02425.1,
EAW79771.1
Ensembl_TRS:
ENST00000326151,
ENST00000394054,
ENST00000326172
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000377618,
ENSP00000325593,
ENSP00000325663
RefSeq:
NP_001005474.1,
NP_113607.1
|
| Others |
UniRef100:
UniRef100_Q9BYH8
UniRef90:
UniRef90_Q9BYH8
UniRef50:
UniRef50_Q9BYH8
UniGene:
Hs.319171
CCDS:
CCDS2946.1,
CCDS43123.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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