| Type | Description |
|---|---|
| Definition | COP1 E3 ubiquitin ligase |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 11:07:00 | Palmitate induces COP1 expression in hepG2 cells. COP1 functioned as an E3 Ub-ligase of SIRT1, responsible for its proteasomal degradation under lipotoxic conditions. TRB3 recruited COP1 to SIRT1 to promote its ubiquitination.The TRB3-COP1-SIRT1 pathway played an important role in lipotoxicity leading to insulin resistance in hepatocytes. | 31125554 |
| 2020-04-11 10:36:00 | COP1 role in the proteasomal degradation of ATGL in hepatocytes. | 30926171 |
| 2019-09-14 12:16:00 | COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors. | 29360641 |
| 2018-12-22 12:01:00 | COP1 overexpression inhibits p53 expression induced by fludarabine and promotes ubiquitin-mediated p53 degradation in chronic lymphocytic leukemia cells. | 30423551 |
| 2018-12-22 10:43:00 | miR-103 blocked PI3K/AKT signal pathway by regulation of COP1. These data indicated that miR-103 was up-regulated in drug resistant cells and it may regulate ADR-resistance by regulation of COP1 in AML cells. | 29058777 |
| Type | IDs |
|---|---|
| Synonymous | RFWD2, RNF200 |
| Gene |
UniProtKB-ID:
COP1_HUMAN,
X5DNY7_HUMAN,
X5D7N8_HUMAN
UniprotKB:
Q8NHY2,
X5DNY7,
X5D7N8
UniParc:
UPI0000061E51,
UPI0000E1EE40,
UPI0003E7582F,
UPI0001F78708,
UPI000006FB1E,
UPI00003B0CBF
EMBL:
AF508940,
AL162736,
AF527539,
AK025789,
CH471067,
AK314750,
KJ534930,
AL590723,
AL513329,
BK000438,
KJ534931,
BC094728,
KJ534928,
AY509921,
AL359265,
KJ535076
Ensembl:
ENSG00000143207
KO:
hsa:64326
|
| Nucleutide sequences |
EMBL-CDS:
AAH94728.1,
AHW56715.1,
EAW91000.1,
DAA01050.1,
AAS82851.1,
BAB15239.1,
BAG37289.1,
AAM34692.1,
AHW56568.1,
AAQ08989.1,
AHW56571.1,
AHW56570.1
Ensembl_TRS:
ENST00000474194,
ENST00000367669,
ENST00000308769
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000356641,
ENSP00000310943,
ENSP00000433517
RefSeq:
XP_016857559.1,
XP_016857561.1,
XP_016857568.1,
XP_016857565.1,
XP_011508183.1,
XP_016857553.1,
XP_016857564.1,
XP_016857567.1,
XP_016857560.1,
XP_016857566.1,
XP_016857549.1,
XP_016857558.1,
XP_016857554.1,
XP_016857548.1,
XP_016857550.1,
XP_016857556.1,
NP_071902.2,
XP_016857563.1,
NP_001273573.1,
XP_016857569.1,
XP_005245504.1,
XP_006711550.1,
XP_005245505.1,
XP_016857555.1,
NP_001001740.1,
XP_016857551.1,
XP_016857562.1,
XP_016857552.1
|
| Others |
UniRef100:
UniRef100_Q8NHY2-4,
UniRef100_Q8NHY2,
UniRef100_X5DNY7
UniRef90:
UniRef90_Q8NHY2
UniRef50:
UniRef50_Q8NHY2
UniGene:
Hs.523744
CCDS:
CCDS30944.1,
CCDS44279.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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