| Type | Description |
|---|---|
| Definition | rhomboid 5 homolog 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 11:05:00 | Results revealed that cervical cancer (CC) tissues had higher levels of iRhom1 than adjacent normal tissues. Its increased expression was significantly associated with tumor stage, size, and parametrium invasion as well as poor outcomes. Knockdown of iRhom1 in HeLa cells inhibited cell growth, disrupted the cell cycle, and promoted apoptosis. | 31661139 |
| 2019-04-06 10:48:00 | findings indicate that perturbations of apicobasal polarity by high levels of RHBDF1 is a significant attribute in the development of breast neoplasia. | 29727209 |
| 2019-04-06 10:15:00 | that the regulatory effects of RHBDF1 on epithelial-to-mesenchymal transition and on cell proliferation are partially attributable to the Wnt/beta-catenin signalling pathway | 29654741 |
| 2019-01-26 11:42:00 | RHBDF1 is an indispensable component of the protein trafficking machinery involved in GPCR-mediated EGFR transactivation, and is an attractive therapeutic target for cancer. | 30279141 |
| 2016-09-03 10:19:00 | results explain how loss of the amino terminus in iRhom1 and iRhom2 impairs TNF signaling, despite enhancing ADAM17 activity | 26535007 |
| Type | IDs |
|---|---|
| Synonymous | C16orf8, Dist1, EGFR-RS, gene-89, gene-90, hDist1 |
| Gene |
UniProtKB-ID:
RHDF1_HUMAN
UniprotKB:
Q96CC6
UniParc:
UPI00001A5206
EMBL:
AK026010,
M99624,
AE006462,
CH471112,
Z69719,
AK291177,
BC014425,
DQ431198
Ensembl:
ENSG00000007384
KO:
hsa:64285
|
| Nucleutide sequences |
EMBL-CDS:
BAF83866.1,
AAA02490.1,
CAI95608.1,
EAW85876.1,
ABD95905.1,
AAH14425.1,
EAW85873.1,
AAK61212.1,
BAB15318.1
Ensembl_TRS:
ENST00000262316
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000262316
RefSeq:
NP_071895.3,
XP_006720984.1,
XP_016879046.1,
XP_016879047.1,
XP_016879045.1,
XP_005255555.1,
XP_005255551.1
|
| Others |
UniRef100:
UniRef100_Q96CC6
UniRef90:
UniRef90_Q96CC6
UniRef50:
UniRef50_Q96CC6
UniGene:
Hs.744992
CCDS:
CCDS32344.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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