| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:53:00 | MAP2K4 interacts with Vimentin to activate the PI3K/AKT pathway and promotes breast cancer pathogenesis. | 31761784 |
| 2020-07-11 11:03:00 | The ensemble structures provided more detailed mechanisms for regulating MAP2K4 in addition to those delineated only by the crystal structures in three states. | 31635803 |
| 2020-03-28 10:26:00 | The initial characterization of tumor-suppressing kinases- in particular members of the protein kinase C family, MKK4 of the mitogen-activated protein kinase kinase family, and DAPK3 of the death-associated protein kinase family- laid the foundation for bioinformatic approaches that enable the identification of other tumor-suppressing kinases. | 30548122 |
| 2019-11-23 12:55:00 | high MKK4 expression and its combination with high MKK7 expression both predicted favorable prognosis in resectable pancreatic ductal adenocarcinoma. | 30537492 |
| 2019-06-15 10:17:00 | This study supports a role for NEK9 and MAP2K4 in mediating buparlisib resistance and demonstrates the value of unbiased omic analyses in uncovering resistance mechanisms to targeted therapy in Triple-Negative Breast Cancers. | 29472518 |
| Type | IDs |
|---|---|
| Synonymous | JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1 |
| Gene |
UniProtKB-ID:
MP2K4_HUMAN
UniprotKB:
P45985
UniParc:
UPI00004FB51A,
UPI000012F48E
EMBL:
BT019676,
AF070084,
AK131544,
AF070086,
L36870,
BC060764,
DQ015703,
AK313053,
AF070081,
CH471108,
AF070082,
AF070083,
AF070090,
AC005244,
AF070080,
BC036032,
AF070088,
AF070087,
CR536564,
AC005410,
AF070089,
AF070085,
U17743
Ensembl:
ENSG00000065559
KO:
hsa:6416
|
| Nucleutide sequences |
EMBL-CDS:
AAV38482.1,
BAG54774.1,
AAC24130.1,
AAH60764.1,
EAW89974.1,
CAG38801.1,
AAY22176.1,
EAW89976.1,
AAC50127.1,
BAG35884.1,
AAH36032.1,
AAC41719.1,
EAW89975.1
Ensembl_TRS:
ENST00000353533,
ENST00000415385
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000410402,
ENSP00000262445
RefSeq:
XP_011522279.1,
XP_005256812.1,
NP_003001.1,
XP_005256810.1,
NP_001268364.1,
XP_011522278.1
|
| Others |
UniRef100:
UniRef100_P45985
UniRef90:
UniRef90_P45985
UniRef50:
UniRef50_P45985
UniGene:
Hs.514681
CCDS:
CCDS62095.1,
CCDS11162.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员