| Type | Description |
|---|---|
| Definition | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-02-09 10:44:00 | ENL overcomes polycomb silencing through recruitment of PAF1 via the conserved YEATS domain, which recognizes acetylated histone H3. | 29217648 |
| 2019-01-26 11:17:00 | direct regulation of the stability of MLL1 through its cleavage by taspase1 | 30573454 |
| 2017-07-15 11:40:00 | data identify ENL as a histone acetylation reader that regulates oncogenic transcriptional programs in acute myeloid leukaemia, and suggest that displacement of ENL from chromatin may be a promising epigenetic therapy, alone or in combination with BET inhibitors, for aggressive leukaemia | 28241141 |
| 2015-02-07 11:47:00 | define a specific pairing of two amino acids that creates a salt bridge between MLLT1/3 and AFF proteins that is critically important for MLL-mediated transformation of HPCs | 25282333 |
| 2010-01-21 00:00:00 | An intimate association between MLL and RNA pol II occurs at MLL target genes in vivo that is required for normal initiation and/or transcriptional elongation. | 16199523 |
| Type | IDs |
|---|---|
| Synonymous | AA407901, BAM11, ENL, LTG19 |
| Gene |
UniProtKB-ID:
Q9ERL0_MOUSE
UniprotKB:
Q9ERL0
UniParc:
UPI0000027697
EMBL:
BC053005,
AK156820,
AF298887,
AC073683,
AK144605
Ensembl:
ENSMUSG00000024212
KO:
mmu:64144
|
| Nucleutide sequences |
EMBL-CDS:
AAH53005.1,
BAE33866.1,
AAG22079.1,
BAE25964.1
Ensembl_TRS:
ENSMUST00000025053
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000025053
RefSeq:
NP_071723.1,
XP_006524841.1
|
| Others |
UniRef100:
UniRef100_Q9ERL0
UniRef90:
UniRef90_Q9ERL0
UniRef50:
UniRef50_Q03111
UniGene:
Mm.148748
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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