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64067 NPAS3

64067

NPAS3

neuronal PAS domain protein 3

protein-coding

Homo sapiens

基因描述

Type Description
Definition neuronal PAS domain protein 3

研究结论

Date Results Publications
2019-04-27 12:11:00 NPAS3 is a true transcription factor capable of regulating expression of target genes through their promoters by directly cooperating with ARNT. 30509165
2018-04-07 11:22:00 Study provides a clear, unbiased view of the full spectrum of genes regulated by NPAS1 and NPAS3 and shows that these transcription factors are master regulators of neuropsychiatric function. These findings expose the molecular pathophysiology of NPAS1/3 mutations and provide a striking example of the shared, combinatorial nature of molecular pathways that underlie diagnostically distinct neuropsychiatric conditions. 28499489
2017-12-16 11:02:00 Here the authors examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets. 27782878
2016-06-28 10:28:00 Authors hypothesize that any nucleotide variant at the NPAS3 HAEs may lead to altered susceptibility to schizophrenia. 25982957
2014-08-30 12:35:00 Identification of NPAS3-V304I helps strengthen the hypothesis that NPAS3 is involved in schizophrenia pathogenesis 23337948

名称对应

Type IDs
Synonymous MOP6, PASD6, bHLHe12
Gene
UniProtKB-ID: NPAS3_HUMAN, X5D7M0_HUMAN, X5D988_HUMAN, X5D2Q4_HUMAN
UniprotKB: Q8IXF0, X5D7M0, X5D988, X5D2Q4
UniParc: UPI0000073AA2, UPI00002264B9, UPI00000743C2, UPI0000190F7B, UPI0004437E96, UPI00000743C0, UPI0000070169
EMBL: AY157302, AY157303, KJ534898, AB054576, AB055962, KJ534895, AL079281, KJ534894, AB054575, AF164438
Ensembl: ENSG00000151322
KO: hsa:64067
Nucleutide sequences
EMBL-CDS: BAB21221.1, BAC53756.1, AAO17044.1, BAC53754.1, AAG35180.1, CAB45154.1, AAO17043.1, AHW56535.1, AHW56538.1, AHW56534.1
Ensembl_TRS: ENST00000357798, ENST00000356141, ENST00000548645, ENST00000547068, ENST00000346562
Protein sequencees
Ensembl_PRO: ENSP00000350446, ENSP00000319610, ENSP00000449542, ENSP00000348460, ENSP00000448916
RefSeq: XP_016877076.1, XP_016877074.1, XP_016877071.1, XP_005268049.2, XP_005268048.2, XP_011535374.1, XP_011535371.2, NP_071406.1, XP_011535373.2, NP_775182.1, NP_001158221.1, XP_016877075.1, XP_011535369.1, XP_016877072.1, NP_001159365.1, XP_011535372.1, XP_016877077.1, XP_016877073.1
Others
UniRef100: UniRef100_Q8IXF0-2, UniRef100_X5D7M0, UniRef100_Q8IXF0
UniRef90: UniRef90_Q9QZQ0, UniRef90_Q8IXF0-3
UniRef50: UniRef50_Q9QZQ0, UniRef50_Q8IXF0-3
UniGene: Hs.657892, Hs.675437, Hs.675475
CCDS: CCDS55912.1, CCDS9645.1, CCDS53892.1, CCDS53891.1

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