| Type | Description |
|---|---|
| Definition | p53 apoptosis effector related to PMP22 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-15 19:05:00 | MiR-629 regulates hypoxic pulmonary vascular remodelling by targeting FOXO3 and PERP. | 31240850 |
| 2020-02-08 11:37:00 | increased level of IL 17 and decreased level of PERP may constitute two major factors in the pathogenesis and activity of rheumatoid arthritis | 31926492 |
| 2020-01-04 12:14:00 | Study shows that mutations in PERP, encoding a crucial component of desmosomes, cause both dominant and recessive human keratoderma. Heterozygosity for a C-terminal truncation, which produces a protein that appears to be unstably incorporated into desmosomes, causes Olmsted syndrome with severe periorificial and palmoplantar keratoderma in multiple unrelated kindreds. | 30321533 |
| 2017-10-14 12:50:00 | Downregulation of desmosomal formation transcripts including PERP may contribute to the aggressive phenotype seen in sparsely granulated GH pituitary tumors and their behavior in response to surgery and medical therapy. | 28323918 |
| 2017-06-24 10:44:00 | Expression of p63-tGFP induces apoptosis with marked increase in PERP expression and associated p53 accumulation. Lack of p63 contributes to reduced PERP levels and impaired p53-mediated apoptosis in UM. | 27584665 |
| Type | IDs |
|---|---|
| Synonymous | KCP1, KRTCAP1, PIGPC1, THW, dJ496H19.1 |
| Gene |
UniProtKB-ID:
PERP_HUMAN
UniprotKB:
Q96FX8
UniParc:
UPI00000734A2
EMBL:
AK314526,
AK075082,
AF317550,
AK074585,
CH471051,
AK097958,
AL023582,
AY157578,
AL355362,
AJ251830,
BC010163
Ensembl:
ENSG00000112378
KO:
hsa:64065
|
| Nucleutide sequences |
EMBL-CDS:
BAC11390.1,
EAW47920.1,
EAW47921.1,
BAG37120.1,
CAC17766.1,
AAH10163.1,
BAC11074.1,
BAC05205.1,
AAG35063.1,
AAO13162.1
Ensembl_TRS:
ENST00000421351
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000397157
RefSeq:
XP_024302288.1,
NP_071404.2
|
| Others |
UniRef100:
UniRef100_Q96FX8
UniRef90:
UniRef90_Q96FX8
UniRef50:
UniRef50_Q96FX8
UniGene:
Hs.201446
CCDS:
CCDS5188.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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