| Type | Description |
|---|---|
| Definition | TSPY like 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 12:54:00 | Here we identify the nucleosome assembly protein TSPY-Like 2 (TSPYL2, also known as TSPX, DENTT, and CDA1) as a novel regulator of SIRT1 and p300 function. We demonstrate that, upon DNA damage, TSPYL2 inhibits SIRT1, disrupting its association with target proteins, and promotes p300 acetylation and activation, finally stimulating p53 acetylation and p53-dependent cell death. | 30050056 |
| 2018-09-01 10:37:00 | Genome-wide polysome profiling shows that hCINAP selectively modulates cancer-associated translatome to promote malignancy. | 27477389 |
| 2018-06-02 10:30:00 | Aortic CDA1 expression was downregulated approximately 70% within biopsies from human abdominal aortic aneurysms. | 29311219 |
| 2017-05-20 12:47:00 | TSPY and TSPX exert opposing effects on the transactivation functions of AR and AR-Vs important for various physiological and disease processes sensitive to male sex hormone actions, thereby not only affecting the pathogenesis of male-specific prostate cancer but also likely contributing to sex differences in the health and diseases of man. | 28169398 |
| 2016-11-05 10:51:00 | the extent of the duplicated regions in each case encompassing a minimum of three known disease genes TSPYL2, KDM5C and IQSEC2, is reported. | 26059843 |
| Type | IDs |
|---|---|
| Synonymous | CDA1, CINAP, CTCL, DENTT, HRIHFB2216, NP79, SE204, TSPX |
| Gene |
UniProtKB-ID:
TSYL2_HUMAN
UniprotKB:
Q9H2G4
UniParc:
UPI000004B6D6
EMBL:
AF254794,
BC001566,
AY040871,
AF273046,
AB015345,
AL713652,
BX322635,
BC024270
Ensembl:
ENSG00000184205
KO:
hsa:64061
|
| Nucleutide sequences |
EMBL-CDS:
AAK72407.1,
AAH24270.1,
AAG53596.1,
AAH01566.1,
BAA34802.1,
AAG34906.1,
CAD28461.1
Gene_ORFName:
HRIHFB2216
Ensembl_TRS:
ENST00000375442
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000364591
RefSeq:
NP_071400.1,
XP_016885216.1,
XP_006724655.1,
XP_016885215.1
|
| Others |
UniRef100:
UniRef100_Q9H2G4
UniRef90:
UniRef90_Q9H2G4
UniRef50:
UniRef50_Q9H2G4
UniGene:
Hs.136164,
Hs.592916
CCDS:
CCDS14350.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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