| Type | Description |
|---|---|
| Definition | selectin P ligand |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 11:13:00 | Virion-incorporated host transmembrane proteins PSGL-1 and CD43 inhibit attachment of HIV-1 particles to target cells. Co-clustering of HIV-1 structural protein Gag with PSGL-1 and subsequent progeny virion release contribute to depletion of PSGL-1 from an infected cell surface. In addition, study reports a previously unidentified role for Gag in viral down-regulation of antiviral proteins. | 32193343 |
| 2019-11-23 10:55:00 | VISTA is an acidic pH-selective ligand for PSGL-1 | 31645726 |
| 2019-11-09 11:09:00 | PSGL-1 contributed to cytotoxic CD4 T cell homing to the culprit coronary artery and promoted plaque instability in ACS. | 29962384 |
| 2019-10-19 12:02:00 | Consensus sequence analysis revealed enterovirus 71 with mutations at E145G and S241L and partial mutations at V146I of VP1, and a T to C substitution at nucleotide 494 of the 5'-UTR exhibited higher binding affinity for virus receptor, human P-selectin glycoprotein ligand-1 (hPSGL-1). | 29703921 |
| 2019-06-29 12:08:00 | PSGL-1 was identified as an HIV-1 restriction factor downregulated by HIV-1 Vpu, which binds to PSGL-1 and induces its ubiquitination and degradation through the ubiquitin ligase SCF(beta-TrCP2). | 30833724 |
| Type | IDs |
|---|---|
| Synonymous | CD162, CLA, PSGL-1, PSGL1 |
| Gene |
UniProtKB-ID:
SELPL_HUMAN
UniprotKB:
Q14242
UniParc:
UPI0000135861,
UPI0002065776
EMBL:
U25956,
AK098315,
AC007569,
AC008119,
U02297,
AK298738,
BC029782,
AY331789,
AK298742,
AK290395
Ensembl:
ENSG00000110876
KO:
hsa:6404
|
| Nucleutide sequences |
EMBL-CDS:
BAH12863.1,
BAG60885.1,
BAC05283.1,
AAA74577.1,
AAC50061.1,
AAH29782.1,
AAP81163.1,
BAF83084.1
Ensembl_TRS:
ENST00000228463,
ENST00000550948
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000228463,
ENSP00000447752
RefSeq:
NP_001193538.1,
NP_002997.2
|
| Others |
UniRef100:
UniRef100_Q14242
UniRef90:
UniRef90_Q14242
UniRef50:
UniRef50_Q14242
UniGene:
Hs.591014
CCDS:
CCDS55881.1,
CCDS31895.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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