| Type | Description |
|---|---|
| Definition | glia maturation factor, gamma |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 12:50:00 | findings suggest that GMFG is an important regulator in cellular iron metabolism and macrophage phenotype and could be a novel therapeutic target for modulating macrophage function in immune and metabolic disorders. | 30971398 |
| 2018-03-10 12:03:00 | Gmfg has two separate binding sites on Arp2/3 complex with high (site 1) and low (site 2) affinity. X-ray crystallography revealed closely located positions of Gmfg in site 1. Molecular dynamics simulation allowed determining the binding pocket for Gmfg in site 2. | 29339159 |
| 2014-02-08 10:53:00 | GMF debranches filaments by a mechanism related to cofilin-mediated severing, but in which GMF has evolved to target molecular junctions between actin-related proteins in the Arp2/3 complex and actin subunits in the daughter filament of the branch. | 23727094 |
| 2013-11-30 11:59:00 | The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin. | 23893131 |
| 2010-01-21 00:00:00 | GMFG is a novel factor in actin cytoskeleton reorganization and is expressed preferentially in microvascular endothelial and inflammatory cells in embryonic development. | 16873721 |
| Type | IDs |
|---|---|
| Synonymous | 0610039G16Rik, 2310057N07Rik, AI324845 |
| Gene |
UniProtKB-ID:
GMFG_MOUSE,
A7VJA4_MOUSE,
D3YY16_MOUSE
UniprotKB:
Q9ERL7,
A7VJA4,
D3YY16
UniParc:
UPI00015AA504,
UPI0000027699
EMBL:
AK002834,
AK009967,
AB003588,
AF297221,
AB097120,
AK014214,
AC149606,
BC011488
Ensembl:
ENSMUSG00000060791
KO:
mmu:63986
|
| Nucleutide sequences |
EMBL-CDS:
BAB26617.1,
BAC76941.1,
AAG22804.1,
BAB29210.1,
BAB22392.1,
AAH11488.1,
BAF76657.1
Ensembl_TRS:
ENSMUST00000108292,
ENSMUST00000078845,
ENSMUST00000108289
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000077889,
ENSMUSP00000103927,
ENSMUSP00000103924
RefSeq:
NP_071307.1,
XP_006540336.1,
NP_001364021.1,
NP_001034281.1,
NP_001277479.1
|
| Others |
UniRef100:
UniRef100_Q9ERL7
UniRef90:
UniRef90_Q9ERL7
UniRef50:
UniRef50_Q9ERL7
UniGene:
Mm.194536
CCDS:
CCDS39860.1,
CCDS39859.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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