| Type | Description |
|---|---|
| Definition | NOP2/Sun RNA methyltransferase 3 |
| Date | Results | Publications |
|---|---|---|
| 2017-07-01 13:01:00 | The authors show that the RNA methyltransferase NSUN3 localises to mitochondria and interacts with mt-tRNA(M)(et) to methylate cytosine 34 (C34) at the wobble position. | 27497299 |
| 2017-05-20 13:46:00 | The NSUN3-knockout cells showed strong reduction in mitochondrial protein synthesis and reduced oxygen consumption, leading to deficient mitochondrial activity. It reconstituted formation of 5-methylcytidine (m(5)C) at position 34 (m(5)C34) on mt-tRNA(Met) with recombinant NSUN3 in the presence of AdoMet, demonstrating that NSUN3-mediated m(5)C34 formation initiates f(5)C34 biogenesis. | 27214402 |
| 2009-04-01 21:32:00 | Observational study of gene-disease association. (HuGE Navigator) | 19240061 |
| Type | IDs |
|---|---|
| Synonymous | MST077, MSTP077 |
| Gene |
UniProtKB-ID:
NSUN3_HUMAN
UniprotKB:
Q9H649
UniParc:
UPI00000373B2
EMBL:
BC020602,
BC057238,
AK025762,
AF169972,
AK026262,
AF351612
Ensembl:
ENSG00000178694
KO:
hsa:63899
|
| Nucleutide sequences |
EMBL-CDS:
BAB15234.1,
AAH57238.1,
AAH20602.1,
BAB15417.1,
AAQ13600.1,
AAN76512.1
Gene_ORFName:
UG0651E06,
MSTP077
Ensembl_TRS:
ENST00000314622
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000318986
RefSeq:
XP_024309467.1,
NP_071355.1
|
| Others |
UniRef100:
UniRef100_Q9H649
UniRef90:
UniRef90_Q9H649
UniRef50:
UniRef50_Q9H649
UniGene:
Hs.448003
CCDS:
CCDS2927.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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