| Type | Description |
|---|---|
| Definition | ring finger protein 123 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:03:00 | Excess of the NF-kB p50 subunit generated by the ubiquitin ligase KPC1 suppresses tumors via PD-L1- and chemokines-mediated mechanisms. | 33168738 |
| 2019-04-13 12:13:00 | E3 ubiquitin ligase RNF123 targets LMNB1, Rb protein and LAP2alpha for proteasomal degradation. | 29676528 |
| 2018-05-05 10:58:00 | Findings indicate epigenetic regulation of E3 ubiquitin ligase KPC1 associated with NF-kappa B (NF-kappaB) pathway activation, promoting metastatic melanoma progression. | 28389511 |
| 2017-10-07 11:04:00 | p27 and its cognate ubiquitin ligases, Skp2/KPC/Pirh2, are specifically involved in determining the clinical profiles of lung carcinomas. | 28601655 |
| 2017-08-19 10:29:00 | RNF123 functions as a novel inhibitor of innate antiviral signaling mediated by RIG-I and MDA5, a function that does not depend on its E3 ligase activity. | 27312109 |
| Type | IDs |
|---|---|
| Synonymous | FP1477, KPC1 |
| Gene |
UniProtKB-ID:
RN123_HUMAN
UniprotKB:
Q5XPI4
UniParc:
UPI0000E2627A,
UPI00001D6A07
EMBL:
AL136729,
AK026968,
AF370367,
BC041145,
AY744152,
AK022627,
BC057392,
BC088801,
AC099668,
BC130632
Ensembl:
ENSG00000164068
KO:
hsa:63891
|
| Nucleutide sequences |
EMBL-CDS:
BAB15607.1,
BAB14139.1,
AAH41145.1,
AAU93470.1,
AAQ15203.1,
AAI30633.1,
AAH88801.1,
AAH57392.2,
CAB66663.2
Gene_ORFName:
FP1477
Ensembl_TRS:
ENST00000327697
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000328287
RefSeq:
XP_011532297.1,
NP_071347.2,
XP_016862507.1,
XP_006713348.1
|
| Others |
UniRef100:
UniRef100_Q5XPI4
UniRef90:
UniRef90_Q5XPI4
UniRef50:
UniRef50_Q5XPI4
UniGene:
Hs.553723
CCDS:
CCDS33758.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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