| Type | Description |
|---|---|
| Definition | sodium voltage-gated channel beta subunit 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:54:00 | Sodium channel beta1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis. | 32503841 |
| 2020-05-02 12:02:00 | The sequencing analyses of the SCN1B gene revealed the presence of a new pathogenic variation c.374C>T (p.R125L) in family A and a putative disease-associated haplotype in five families. Using multiple alignments, the c.374G>T changed a highly conserved arginine to a leucine p.R125L located in the extracellular domain of the protein. | 31729702 |
| 2019-12-14 10:49:00 | The S248R and R250T mutations of SCN1Bbeta gene caused gain-of-function of Ito by associated with Kv4.3, which maybe underlie the early repolarization syndrome (ERS) phenotype of the probands. | 30160358 |
| 2019-08-24 10:50:00 | this study reports the cryo-electron microscopy structures of the human Nav1.7-beta1-beta2 complex bound to two combinations of pore blockers and gating modifier toxins (GMTs), tetrodotoxin with protoxin-II and saxitoxin with huwentoxin-IV, both determined at overall resolutions of 3.2 angstroms. | 30765606 |
| 2019-08-17 12:15:00 | our results show that the role of beta1 subunit on the maturation and expression of the entire NaCh complex is of paramount importance to understand the pathological conditions resulted from a defective interaction between the NaCh constituents. | 29992740 |
| Type | IDs |
|---|---|
| Synonymous | ATFB13, BRGDA5, EIEE52, GEFSP1 |
| Gene |
UniProtKB-ID:
SCN1B_HUMAN,
A0A1W2PR05_HUMAN
UniprotKB:
Q07699,
A0A1W2PR05
UniParc:
UPI00000473F0,
UPI00000532B2,
UPI000006DD80
EMBL:
BC067122,
DQ677665,
AC020907,
AK313279,
U12189,
U12192,
L10338,
U12190,
U12191,
AY391842,
U12193,
BT019923,
L16242
Ensembl:
ENSG00000105711
KO:
hsa:6324
|
| Nucleutide sequences |
EMBL-CDS:
AAA61277.1,
AAB97608.1,
AAH67122.1,
AAA60391.1,
AAR25552.1,
AAV38726.1,
ABQ01236.1,
BAG36087.1
Ensembl_TRS:
ENST00000415950,
ENST00000262631,
ENST00000638536,
ENST00000596348
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000396915,
ENSP00000492022,
ENSP00000262631,
ENSP00000492247
RefSeq:
NP_950238.1,
NP_001308534.1,
NP_001028.1
|
| Others |
UniRef100:
UniRef100_Q07699
UniRef90:
UniRef90_Q07699
UniRef50:
UniRef50_Q07699
UniGene:
Hs.436646
CCDS:
CCDS12441.1,
CCDS46047.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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