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625249 Gpx4

625249

Gpx4

glutathione peroxidase 4

protein-coding

Mus musculus

基因描述

Type Description
Definition glutathione peroxidase 4

研究结论

Date Results Publications
2020-10-24 14:10:00 Redox homeostasis maintained by GPX4 facilitates STING activation. 32541831
2019-10-26 11:48:00 results clearly show that mRNA expression for all three GPx4 isoforms (cytoplasmic, mitochondrial and nuclear) decline in multiple sclerosis gray matter and in the spinal cord of mice with experimental autoimmune encephalomyelitis 30289974
2019-02-09 10:10:00 Genetic inactivation of GPX4 increases lipid peroxidation, thus exacerbating GSDMD-mediated pyroptosis in macrophages as well as septic lethality in mice. 29937272
2019-01-19 11:14:00 Selenium-containing GPX4 is necessary for full viability of mice. Survival of a specific type of interneurons depends on selenocysteine-containing GPX4, thereby preventing fatal epileptic seizures. 29290465
2018-12-22 12:17:00 paternal acetylated histones and acrosomal nuclear GPx4 are directly involved in fertilization. 28802016

名称对应

Type IDs
Synonymous GPx-4, GSHPx-4, PHGPx, mtPHGPx, snGPx
Gene
UniProtKB-ID: GPX4_MOUSE, Q76LV0_MOUSE
UniprotKB: O70325, Q76LV0
UniParc: UPI000016C783, UPI0000163838, UPI0000169292
EMBL: AK006441, AB030728, D87896, AB030643, AF044056, AF045768, AF045769, AB072797, AF274027, AJ012104
Ensembl: ENSMUSG00000075706
KO: mmu:625249
Nucleutide sequences
EMBL-CDS: AAC15832.1, BAC06511.1, BAC06509.1, BAC55251.1, BAC06508.1, BAC06507.1, CAB42657.2, AAK74112.1, AAC14560.1, BAA22780.1, AAC15833.1, BAC87835.1
Ensembl_TRS: ENSMUST00000097227, ENSMUST00000105372
Protein sequencees
Ensembl_PRO: ENSMUSP00000094863, ENSMUSP00000101011
RefSeq: NP_032188.3, NP_001032830.2, NP_001354924.1
Others
UniRef100: UniRef100_O70325, UniRef100_Q76LV0
UniRef90: UniRef90_P36970-3, UniRef90_O70325
UniRef50: UniRef50_P36970-3, UniRef50_O70325
UniGene: Mm.359573
CCDS: CCDS35973.1, CCDS24007.1

全选

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