| Type | Description |
|---|---|
| Definition | protein kinase cAMP-dependent type I regulatory subunit alpha |
| Date | Results | Publications |
|---|---|---|
| 2017-08-12 11:52:00 | Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit) | 28661131 |
| 2016-05-28 10:29:00 | Data suggest PRKAR1A contains two structurally homologous cAMP-binding domains that exhibit marked differences in dynamic profiles in activation/inhibition of Prkaca; conservation of structure does not necessarily imply conservation of dynamics. | 26618408 |
| 2010-06-28 11:58:00 | Thermodynamic analysis of protein kinase A Ialpha activation was performed using Quantum 3.3.0 docking software and a Gaussian 03W quantum mechanical computational package. | 20367611 |
| 2010-05-31 11:43:00 | Results describe the structures of the protein kinase A RIalpha subunit D/D domain alone and in complex with D-AKAP2. | 20159461 |
| 2010-05-03 12:14:00 | Data show that RSK1 regulates activity in a cAMP-independent manner, and by associating with RSK1 regulates its activation and its biological functions. | 20048145 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
KAP0_BOVIN
UniprotKB:
P00514
UniParc:
UPI0000DA5947
EMBL:
BT030573,
K00833,
BC118242
Ensembl:
ENSBTAG00000008621
KO:
bta:615074
|
| Nucleutide sequences |
EMBL-CDS:
AAA30708.1,
AAI18243.1,
ABQ13013.1
Ensembl_TRS:
ENSBTAT00000011371
|
| Protein sequencees |
Ensembl_PRO:
ENSBTAP00000011371
RefSeq:
XP_024836190.1,
NP_001069826.1,
XP_024836191.1
|
| Others |
UniRef100:
UniRef100_P00514
UniRef90:
UniRef90_P10644
UniRef50:
UniRef50_P10644
UniGene:
Bt.10903
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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