| Type | Description |
|---|---|
| Definition | RIC8 guanine nucleotide exchange factor A |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:39:00 | Structures of Galpha Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms. | 32126208 |
| 2019-10-19 11:50:00 | These results indicate that dual phosphorylation represents a critical form of conserved Ric-8 regulation and demonstrate that Ric-8 proteins are needed for effective Galpha signaling. | 29844055 |
| 2015-11-21 10:30:00 | Human NCS-1 and Ric8a reproduce the binding and maintain the structural requirements at these key positions. Drosophila Ric8a and Galphas regulate synapse number and neurotransmitter release, and both are functionally linked to Frq2. | 25074811 |
| 2015-10-03 10:52:00 | Results confirmed that Ric-8A can directly bind to AGS3S but failed to facilitate Galpha(i)-induced suppression of adenylyl cyclase, suggesting that it may not serve as a guanine exchange factor for AGS3/Galpha(i/o)-GDP complex in a cellular environment. | 25480567 |
| 2014-09-20 12:01:00 | Ric-8A co-localized with Vps34 at the midbody. | 24466196 |
| Type | IDs |
|---|---|
| Synonymous | RIC8 |
| Gene |
UniProtKB-ID:
RIC8A_HUMAN
UniprotKB:
Q9NPQ8
UniParc:
UPI000006DE38,
UPI000067CA62,
UPI0000037C19,
UPI0000EE8145
EMBL:
BX538115,
AK027461,
BC121808,
AK027090,
AC069287,
AL136935,
AL390088,
BC121807,
BC111499,
BC011821,
AK022870
Ensembl:
ENSG00000177963
KO:
hsa:60626
|
| Nucleutide sequences |
EMBL-CDS:
BAB15653.1,
CAB66869.1,
AAH11821.2,
BAB14282.1,
AAI21808.1,
AAI11500.1,
CAB98211.1,
BAB55126.1,
CAD98025.1,
AAI21809.1
Ensembl_TRS:
ENST00000527696,
ENST00000325207,
ENST00000526104
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000434833,
ENSP00000432008,
ENSP00000325941
RefSeq:
NP_068751.4,
NP_001373870.1,
NP_001373871.1,
NP_001273063.1
|
| Others |
UniRef100:
UniRef100_Q9NPQ8
UniRef90:
UniRef90_Q9NPQ8
UniRef50:
UniRef50_Q9NPQ8
UniGene:
Hs.592292
CCDS:
CCDS7690.1,
CCDS65982.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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