| Type | Description |
|---|---|
| Definition | guanylate cyclase 1, soluble, alpha 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-16 13:00:00 | These studies identify MEK/ERK signaling as an important pathway by which TGFbeta regulates sGC expression in pulmonary artery smooth muscle cell. | 30260287 |
| 2018-09-15 11:00:00 | Study shows notch signaling provides a constitutive drive on expression of the major nitric oxide receptor GUCY1A3 and GUCY1B3 in arteries from mice. | 28465505 |
| 2017-09-30 10:21:00 | Exogenous or paracrine sources of NO promote the specification towards the myocyte lineage and expression of cardiac sarcomeric proteins of adult cardiac progenitor cells. This is contingent upon the expression and activity of the alpha1 subunit of guanylyl cyclase in CPC that is necessary for NO-mediated inhibition of the canonical Wnt/beta-catenin pathway. | 27520736 |
| 2017-08-12 12:02:00 | These data demonstrate that a reduction in cardiac sGC activity worsens doxorubicin-induced cardiotoxicity in mice and identify sGC as a potential therapeutic target. | 27505125 |
| 2017-05-20 14:24:00 | We suggest that Gucy1a3 activity promotes the phenotypic switching of smooth muscle cells from a contractile to a synthetic state, fostering the formation of atherosclerosis. | 27315776 |
| Type | IDs |
|---|---|
| Synonymous | 1200016O07Rik, GCS-alpha-1, GCS-alpha-3, Gucy1a3, sGC-alpha1 |
| Gene |
UniProtKB-ID:
GCYA1_MOUSE
UniprotKB:
Q9ERL9
UniParc:
UPI0000003F71
EMBL:
AF297082,
BC057327,
BC094310,
AK028558,
AK004815
Ensembl:
ENSMUSG00000033910
KO:
mmu:60596
|
| Nucleutide sequences |
EMBL-CDS:
AAH57327.1,
BAB23586.1,
AAG17446.1,
BAC26009.1,
AAH94310.1
Ensembl_TRS:
ENSMUST00000193924,
ENSMUST00000048976
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000142138,
ENSMUSP00000048918
RefSeq:
NP_068696.2,
NP_001343917.1,
NP_001343916.1
|
| Others |
UniRef100:
UniRef100_Q9ERL9
UniRef90:
UniRef90_Q02108
UniRef50:
UniRef50_Q02108
UniGene:
Mm.143831
CCDS:
CCDS17429.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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