| Type | Description |
|---|---|
| Definition | salvador family WW domain containing protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:28:00 | RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer. | 32780197 |
| 2020-02-15 10:18:00 | BCL-2 is a new regulator of MST pathway. First, protein levels of MST2 and SAV1 were reduced significantly by co-expression of BCL-2. Physical interaction of BCL-2 with SAV1 was correlated with proteasomal degradation of SAV1 and MST2 proteins. | 30867124 |
| 2019-05-04 10:20:00 | Authors report that SAV1, a Hippo signaling component, inhibits Akt, a function independent of its role in Hippo signaling. Binding to a proline-tyrosine motif in the Akt-PH domain, SAV1 suppresses Akt activation by blocking Akt's movement to plasma membrane. Authors further identify cancer-associated SAV1 mutations with impaired ability to bind Akt, leading to Akt hyperactivation. | 30944303 |
| 2019-04-20 12:42:00 | SAV1 suppresses tumor growth in colorectal cancer and is regulated by miR-21. | 30681889 |
| 2018-12-22 10:21:00 | These results suggest Salvador enhances the effects of Hippo kinase activity at multiple points in the Hippo pathway. | 29519817 |
| Type | IDs |
|---|---|
| Synonymous | SAV, WW45, WWP4 |
| Gene |
UniProtKB-ID:
SAV1_HUMAN,
B3KTQ1_HUMAN
UniprotKB:
Q9H4B6,
B3KTQ1
UniParc:
UPI00001FD4F2,
UPI0000035DA2
EMBL:
AK290883,
CR457297,
BC020537,
AK023071,
AK021500,
AJ292969,
AK095903,
CH471078
Ensembl:
ENSG00000151748
KO:
hsa:60485
|
| Nucleutide sequences |
EMBL-CDS:
AAH20537.1,
BAB13835.1,
BAB14390.1,
CAC13972.1,
CAG33578.1,
EAW65702.1,
EAW65704.1,
BAF83572.1,
BAG53163.1
Ensembl_TRS:
ENST00000324679
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000324729
RefSeq:
NP_068590.1,
XP_011535359.1,
XP_016877057.1
|
| Others |
UniRef100:
UniRef100_Q9H4B6
UniRef90:
UniRef90_Q8VEB2
UniRef50:
UniRef50_Q8VEB2
UniGene:
Hs.642842,
Hs.706933
CCDS:
CCDS9701.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员