| Type | Description |
|---|---|
| Definition | ring finger protein 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:25:00 | Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP. | 32054686 |
| 2020-07-11 12:15:00 | Authors demonstrate that the V proteins of NDV and several other paramyxoviruses target MAVS for ubiquitin-mediated degradation through E3 ubiquitin ligase RING-finger protein 5 (RNF5). MAVS degradation leads to the inhibition of the downstream IFN-beta pathway and therefore benefits virus proliferation. | 31270229 |
| 2016-08-13 10:07:00 | we found that RNF5 is differentially expressed in human bronchial epithelia from CF vs. control patients. Our results identify RNF5 as a target for therapeutic modalities to antagonize mutant CFTR proteins. | 26183966 |
| 2015-05-23 11:28:00 | RNF5 is involved in the regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2. | 25759021 |
| 2014-04-05 12:19:00 | Our data suggest that RNF5 regulates the turnover of specific G protein-coupled receptors by ubiquitinating JAMP and preventing proteasome recruitment. | 23798571 |
| Type | IDs |
|---|---|
| Synonymous | RING5, RMA1 |
| Gene |
UniProtKB-ID:
RNF5_HUMAN,
A0A024RCQ4_HUMAN
UniprotKB:
Q99942,
A0A024RCQ4
UniParc:
UPI000006D329
EMBL:
BC127652,
KY500604,
AL845464,
AK311859,
AL662830,
BT007105,
U89336,
BC127651,
BC119742,
BX927239,
KY500603,
CH471081,
KY500602,
BX284686,
AB056869,
KY500605,
BC004155,
AJ243936,
BC111392,
CR812478,
BC119741,
BC148255,
CR933878,
AL662884
Ensembl:
ENSG00000204308,
ENSG00000228907,
ENSG00000227277,
ENSG00000228405,
ENSG00000223767,
ENSG00000225452,
ENSG00000183574
KO:
hsa:6048
|
| Nucleutide sequences |
EMBL-CDS:
AAI27652.1,
AAP35769.1,
AAI27653.1,
AAH04155.1,
AAI48256.1,
AAI19743.1,
CAB51286.1,
AAI19742.1,
AAB47492.1,
AAI11393.1,
BAB39359.1,
BAG34800.1,
AQY77077.2,
EAX03607.1,
AQY77075.2,
AQY77074.2,
EAX03609.1,
AQY77076.2
Gene_ORFName:
hCG_1999929
Ensembl_TRS:
ENST00000432616,
ENST00000445885,
ENST00000449794,
ENST00000375094,
ENST00000453473,
ENST00000413786,
ENST00000456167
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000413131,
ENSP00000388795,
ENSP00000415784,
ENSP00000415127,
ENSP00000364235,
ENSP00000401172,
ENSP00000387879
RefSeq:
NP_008844.1
|
| Others |
UniRef100:
UniRef100_Q99942
UniRef90:
UniRef90_Q99942
UniRef50:
UniRef50_Q99942
UniGene:
Hs.731774
CCDS:
CCDS4745.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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