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6046 BRD2

6046

BRD2

bromodomain containing 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition bromodomain containing 2

研究结论

Date Results Publications
2020-10-24 13:58:00 Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system. 31792058
2020-05-02 12:10:00 There is a uniform low average percentage of BRD2 promoter CpG methylation (<4.5%) for 13 CpG76-CpGs in whole blood cells from 782 unrelated European Caucasian. (SNP) rs3918149 alleles were not associated with JME or CpG76 methylation. Our results do not support the previous observation that a high DNA methylation level of the BRD2 promoter CpG76 island is a prevalent epigenetic motif associated with JME in Caucasians. 30719712
2020-01-11 11:32:00 a number of genes important for keratinocyte homeostasis and cornification were dysregulated in BRD2-deficient keratinocytes. In IL17A/TNF/IL22 stimulated three-dimensional organotypic raft cultures, pan-BRD inhibition reduced inflammatory factor production but elicited aberrant cornification, consistent with RNA-Seq analysis 30938974
2019-12-14 12:04:00 These data suggest that LYAR promotes the association of the BRD2-KAT7 and BRD4-KAT7 complexes with transcription-competent rDNA loci but not to transcriptionally silent rDNA loci, thereby increasing rRNA synthesis by altering the local acetylation status of histone H3 and H4. 31504794
2019-08-03 12:26:00 Results provide evidence that BRD2 is a positive regulator of epithelial-to-mesenchymal transition in breast cancer cells. 29437854

名称对应

Type IDs
Synonymous BRD2-IT1, D6S113E, FSH, FSRG1, NAT, O27.1.1, RING3, RNF3
Gene
UniProtKB-ID: BRD2_HUMAN, X5CF57_HUMAN, A0A1U9X7A8_HUMAN, A0A024RCR5_HUMAN
UniprotKB: P25440, X5CF57, A0A1U9X7A8, A0A024RCR5
UniParc: UPI0000227E6A, UPI0000126ACC, UPI000015B7B9, UPI00004402FD
EMBL: Z96104, AL832722, CR936909, KY500178, KY500171, KY500175, KJ657696, BX908719, AL662845, BX005422, KJ657695, KY500177, KY500173, KJ657694, KJ657697, BX647233, CH471081, X96670, AL935042, AL805913, BC063840, KY500172, X62083, BX648109, AL645941, D42040, M80613
Ensembl: ENSG00000234704, ENSG00000204256, ENSG00000215077, ENSG00000234507, ENSG00000235307
KO: hsa:6046
Nucleutide sequences
EMBL-CDS: CAA65450.1, CAA43996.1, BAA07641.1, CAH56208.1, EAX03663.1, AAA68890.1, CAC69989.1, EAX03662.1, CAH56179.1, CAH56171.1, AAH63840.1, AHW47947.1, AHW47981.1, AHW47964.1, AHW47930.1, AQY76682.1, AQY76681.1, AQY76676.1, AQY76675.1, AQY76679.1, AQY76677.1, EAX03664.1, EAX03666.1
Gene_ORFName: hCG_17503
Ensembl_TRS: ENST00000395287, ENST00000374825, ENST00000442863, ENST00000399527, ENST00000449085, ENST00000383108, ENST00000436979, ENST00000399529, ENST00000449118, ENST00000552587, ENST00000414731, ENST00000438194, ENST00000549126, ENST00000399528, ENST00000374831, ENST00000448067
Protein sequencees
Ensembl_PRO: ENSP00000401791, ENSP00000409145, ENSP00000372588, ENSP00000382444, ENSP00000382445, ENSP00000410994, ENSP00000363964, ENSP00000399009, ENSP00000378702, ENSP00000405634, ENSP00000449609, ENSP00000363958, ENSP00000391246, ENSP00000449380, ENSP00000412885, ENSP00000382443
RefSeq: NP_001106653.1, NP_001186384.1, NP_001186385.1, NP_001278915.1, NP_005095.1
Others
UniRef100: UniRef100_P25440, UniRef100_X5CF57
UniRef90: UniRef90_P25440
UniRef50: UniRef50_P25440
UniGene: Hs.75243
CCDS: CCDS56420.1, CCDS4762.1, CCDS56421.1

全选

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