| Type | Description |
|---|---|
| Definition | ribonuclease L |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:46:00 | Sunitinib inhibits RNase L by destabilizing its active dimer conformation. | 32830849 |
| 2020-10-24 14:03:00 | RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules. | 31896577 |
| 2020-03-21 10:39:00 | Our data show that rs486907 was not associated with the risk of prostate cancer in any populations. Nevertheless, rs627928 was reported to promote the development of prostate cancer (T vs. G: OR=1.08, 95% CI=1.01-1.15; TT+TG vs. GG: OR=1.14, 95% CI=1.03-1.25) in allele and recessive models in overall populations. | 31686670 |
| 2019-12-14 10:04:00 | The dependence on expression of ZAP antiviral protein (ZAP), 2'-5'-oligoadenylate synthetase (OAS3) and 2-5A-dependent ribonuclease (RNAseL) for CpG/UpA-mediated attenuation and the variable and often low level expression of these pathway proteins in certain cell types. | 31276592 |
| 2018-11-10 12:07:00 | Mitochondrial C11orf83 is a potent antiviral protein independent of interferon production; and knockdown of either OAS3 or RNase L impaired the antiviral capability of C11orf83. | 28418037 |
| Type | IDs |
|---|---|
| Synonymous | PRCA1, RNS4 |
| Gene |
UniProtKB-ID:
RN5A_HUMAN
UniprotKB:
Q05823
UniParc:
UPI000005339F,
UPI0000401FA7
EMBL:
L10381,
AL138776,
CR627369,
BC114433,
CH471067,
BC090934
Ensembl:
ENSG00000135828
KO:
hsa:6041
|
| Nucleutide sequences |
EMBL-CDS:
AAI14434.1,
EAW91128.1,
AAA18032.1,
CAH10468.1,
AAH90934.1
Ensembl_TRS:
ENST00000539397,
ENST00000367559
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000356530,
ENSP00000440844
RefSeq:
NP_066956.1
|
| Others |
UniRef100:
UniRef100_Q05823
UniRef90:
UniRef90_Q05823
UniRef50:
UniRef50_Q05823
UniGene:
Hs.518545
CCDS:
CCDS1347.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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