| Type | Description |
|---|---|
| Definition | solute carrier family 25 member 19 |
| Date | Results | Publications |
|---|---|---|
| 2017-11-26 01:13:00 | Pancreatic acinar cells Mitochondrial Thiamin Pyrophosphate uptake process is adaptively regulated by the prevailing thiamin level and this regulation is exerted at the level of transcription of the SLC25A19 gene and involves transcription factor binding affinity/epigenetic mechanisms. | 28729247 |
| 2017-10-28 11:21:00 | Among 6 residues predicted by the docking model ( Thr(29), Arg(30), Ile(33), Ser(34), Asp(37) and Phe(298)), only Ile(33), Ser(34) and Asp(37) were critical for function. Ser(34) did not affect translation/stability. Ile(33) and Asp(37) mutants decreased this parameter andwere expressed less in mitochondria. A polar residue was needed at position 34. His(137) and Lys(291) are needed for delivery to mitochondria. | 27188525 |
| 2016-02-13 10:13:00 | Chronic alcohol exposure negatively impacts pancreatic mitochondrial thiamin pyrophosphate transport, and this effect is exerted, at least in part, at the level of Slc25a19 transcription and appears to involve an epigenetic mechanism. | 26316591 |
| 2014-03-08 12:05:00 | These findings demonstrate that the genes involved in dictating thiamine homeostasis, such as SLC19A2, SLC25A19 and TPK-1, were significantly up-regulated in clinical tissues and breast cancer cell lines. | 23642734 |
| 2013-11-16 11:51:00 | Characterization of the SLC25A19 promoter and demonstration of an essential role for NF-Y in its basal activity. | 23872534 |
| Type | IDs |
|---|---|
| Synonymous | DNC, MCPHA, MUP1, THMD3, THMD4, TPC |
| Gene |
UniProtKB-ID:
TPC_HUMAN,
Q5JPC1_HUMAN
UniprotKB:
Q9HC21,
Q5JPC1
UniParc:
UPI000012963A,
UPI0000D6238D
EMBL:
AK097882,
BC001075,
AF182404,
AC022211,
BC005120,
CH471099,
AL833387,
AJ301616,
AJ251857,
AY346372
Ensembl:
ENSG00000125454
KO:
hsa:60386
|
| Nucleutide sequences |
EMBL-CDS:
AAH05120.1,
AAH01075.1,
AAQ54327.1,
CAC37793.1,
AAG16903.1,
CAC27560.1,
BAG53545.1,
CAI46136.1,
EAW89269.1,
EAW89267.1,
EAW89268.1
Gene_ORFName:
hCG_27461
Ensembl_TRS:
ENST00000442286,
ENST00000580994,
ENST00000375261,
ENST00000416858,
ENST00000320362,
ENST00000402418
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000463795,
ENSP00000319574,
ENSP00000364410,
ENSP00000402202,
ENSP00000397818,
ENSP00000385312
RefSeq:
XP_005257619.1,
XP_016880417.1,
XP_005257617.1,
NP_001119594.1,
NP_001119593.1,
XP_006722070.1,
XP_016880416.1,
NP_068380.3,
XP_005257618.1,
XP_005257616.1,
XP_016880415.1
|
| Others |
UniRef100:
UniRef100_Q9HC21
UniRef90:
UniRef90_Q9HC21
UniRef50:
UniRef50_Q9HC21
UniGene:
Hs.514470
CCDS:
CCDS11720.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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