RGS7 - regulator of G protein signaling 7-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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6000 RGS7

基因描述

Type	Description
Definition	regulator of G protein signaling 7

研究结论

Date	Results	Publications
2019-04-27 11:36:00	Data mapped differences in deuterium exchange between the regulator of G protein signaling 7 (RGS7)-Gbeta5 protein(Gbeta5)-RGS7 family binding protein (R7BP) trimer and the RGS7-Gbeta5 dimer.	30540250
2018-12-01 11:29:00	Results found that RGS7 was mutated in 11% of melanomas with three recurrent mutations (p.R44C, p.E383K and p.R416Q). p.R44C was shown to destabilize the protein due to the loss of an H-bond and salt bridge. RGS7 p.R44C has weaker catalytic activity for its substrate Galphao, thus providing a dual mechanism for its loss of function resulting in increase anchorage-independent growth, migration and invasion of melanoma c...	29330521
2017-07-08 11:49:00	Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit 13)	28432124
2016-11-05 12:02:00	R7-binding protein had a strong inhibitory effect on homo-oligomerization of RGS7.	26895961
2016-04-16 11:51:00	Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval	26113603

名称对应

Type	IDs
Gene	UniProtKB-ID: RGS7_HUMAN, B7Z257_HUMAN, B7Z223_HUMAN UniprotKB: P49802, B7Z257, B7Z223 UniParc: UPI000002B25A, UPI0001914D81, UPI0000133827, UPI000002B259, UPI0001914B45, UPI000040E182, UPI000002B25B EMBL: AY587875, AF493930, AL590682, AL359764, AF090117, U32439, AK294234, AK294354, AL365184, AL512307, CH471098, BC022009, AF493931, AF090116 Ensembl: ENSG00000182901 KO: hsa:6000
Nucleutide sequences	EMBL-CDS: EAW70086.1, AAD34290.1, AAT52231.1, AAD34291.1, AAH22009.1, AAM12645.1, AAC50351.1, AAM12644.1, BAH11743.1, BAH11709.1 Ensembl_TRS: ENST00000366563, ENST00000348120, ENST00000366564, ENST00000366565
Protein sequencees	Ensembl_PRO: ENSP00000341242, ENSP00000355523, ENSP00000355522, ENSP00000355521 RefSeq: XP_016857494.1, XP_006711863.1, NP_001361736.1, NP_001337042.1, XP_016857500.1, NP_001361743.1, XP_016857501.1, NP_001337043.1, XP_011542549.1, NP_001361744.1, NP_002915.3, NP_001361745.1, NP_001337044.1, NP_001269704.1, XP_011542548.1, NP_001361740.1, NP_001361739.1, NP_001361741.1, XP_016857491.1, NP_001361742.1, NP_001337045.1, NP_001361738.1, XP_016857498.1, XP_016857490.1, NP_001361735.1, NP_001269707.1, XP_016857502.1, NP_001361737.1, NP_001269702.1, NP_001351815.1
Others	UniRef100: UniRef100_P49802, UniRef100_F7GRL4 UniRef90: UniRef90_P49802 UniRef50: UniRef50_P49802 UniGene: Hs.655739 CCDS: CCDS60457.1, CCDS31071.1, CCDS60459.1, CCDS60458.1

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mRNA

Protein

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Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
30540250	Structural organization of a major neuronal G protein regulator, the RGS7-GÎ²5-R7BP complex. Elife Dipak N Patil , Erumbi S Rangarajan , Scott J Novick , Bruce D Pascal , Douglas J Kojetin , Patrick R Griffin , Tina Izard , Kirill A Martemyanov	2018-12-12	-
30021884	Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Mol Cell Proteomics Domenico Fasci , Hugo van Ingen , Richard A Scheltema , Albert J R Heck	2018-10-01	-
29987050	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Proc. Natl. Acad. Sci. U.S.A. Tengfei Xiao , Wei Li , Xiaoqing Wang , Han Xu , Jixin Yang , Qiu Wu , Ying Huang , Joseph Geradts , Peng Jiang , Teng Fei , David Chi , Chongzhi Zang , Qi Liao , Jonathan Rennhack , Eran Andrechek , Nanlin Li , Simone Detre , Mitchell Dowsett , Rinath M Jeselsohn , X Shirley Liu , Myles Brown	2018-07-31	-
29330521	RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells. Sci Rep Nouar Qutob , Ikuo Masuho , Michal Alon , Rafi Emmanuel , Isadora Cohen , Antonella Di Pizio , Jason Madore , Abdel Elkahloun , Tamar Ziv , Ronen Levy , Jared J Gartner , Victoria K Hill , Jimmy C Lin , Yael Hevroni , Polina Greenberg , Alexandra Brodezki , Steven A Rosenberg , Mickey Kosloff , Nicholas K Hayward , Arie Admon , Masha Y Niv , Richard A Scolyer , Kirill A Martemyanov , Yardena Samuels	2018-01-12	-
28432124	Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit GÎ±₁₃. J Biol Chem Stephanie L Scherer , Matthew D Cain , Stanley M Kanai , Kevin M Kaltenbronn , Kendall J Blumer	2017-06-16	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
26895961	Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by GÎ±o and R7-binding Protein. J Biol Chem Junior Tayou , Qiang Wang , Geeng-Fu Jang , Alexey N Pronin , Cesare Orlandi , Kirill A Martemyanov , John W Crabb , Vladlen Z Slepak	2016-04-22	-
26113603	Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval. Endocr. Relat. Cancer Brahim Aissani , Kui Zhang , Arjen R Mensenkamp , Fred H Menko , Howard W Wiener	2015-08-01	-
26186194	The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell Edward L Huttlin , Lily Ting , Raphael J Bruckner , Fana Gebreab , Melanie P Gygi , John Szpyt , Stanley Tam , Gabriela Zarraga , Greg Colby , Kurt Baltier , Rui Dong , Virginia Guarani , Laura Pontano Vaites , Alban Ordureau , Ramin Rad , Brian K Erickson , Martin WÃ¼hr , Joel Chick , Bo Zhai , Deepak Kolippakkam , Julian Mintseris , Robert A Obar , Tim Harris , Spyros Artavanis-Tsakonas , Mathew E Sowa , Pietro De Camilli , Joao A Paulo , J Wade Harper , Steven P Gygi	2015-07-16	-
25199915	GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. Linda Broer , Aron S Buchman , Joris Deelen , Daniel S Evans , Jessica D Faul , Kathryn L Lunetta , Paola Sebastiani , Jennifer A Smith , Albert V Smith , Toshiko Tanaka , Lei Yu , Alice M Arnold , Thor Aspelund , Emelia J Benjamin , Philip L De Jager , Gudny Eirkisdottir , Denis A Evans , Melissa E Garcia , Albert Hofman , Robert C Kaplan , Sharon L R Kardia , Douglas P Kiel , Ben A Oostra , Eric S Orwoll , Neeta Parimi , Bruce M Psaty , Fernando Rivadeneira , Jerome I Rotter , Sudha Seshadri , Andrew Singleton , Henning Tiemeier , AndrÃ© G Uitterlinden , Wei Zhao , Stefania Bandinelli , David A Bennett , Luigi Ferrucci , Vilmundur Gudnason , Tamara B Harris , David Karasik , Lenore J Launer , Thomas T Perls , P Eline Slagboom , Gregory J Tranah , David R Weir , Anne B Newman , Cornelia M van Duijn , Joanne M Murabito	2015-01-01	-

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