| Type | Description |
|---|---|
| Definition | RELB proto-oncogene, NF-kB subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:13:00 | Switch of NAD Salvage to de novo Biosynthesis Sustains SIRT1-RelB-Dependent Inflammatory Tolerance. | 31681271 |
| 2020-07-18 12:20:00 | Study demonstrated that tristetraprolin (TTP) binds to multiple intronic and exonic sites in the pre-mRNA/mRNA of the transcription factor RelB, correlating with the TTP-upregulated expression of RelB. These findings support a model in which TTP binding of RelB pre-mRNA/mRNA coordinates the RelB upregulation and activation of the innate immunity for antiviral response. | 32163759 |
| 2020-03-14 10:11:00 | Active RelB/p52 translocate into the nucleus to bind NF-kappaB response element of target gene promoter, and in turn, elicit recruitment of CBP and/or HDAC1 to regulate H3K9ac for epigenetic induction of parturition triggers | 30642670 |
| 2020-02-15 10:40:00 | Astrocytes display days-to-weeks long specific tolerance of cytokine genes, which is coordinated by NF-kappaB family member, RelB. However, in contrast to innate immune cells, astrocytic tolerance does not involve epigenetic silencing of the cytokine genes. Establishment of tolerance depends on persistent higher levels of RelB in tolerant astrocytes and its phosphorylation on serine 472. | 30957303 |
| 2019-12-14 11:29:00 | Study reports that PAK4 is overexpressed in all human breast cancer subtypes and associated with poor outcome. PAK4 prevents senescence-like growth arrest in breast cancer cells in vitro, in vivo and ex vivo. PAK4-RELB-C/EBPbeta axis controls the senescence-like growth arrest and a PAK4 phosphorylation residue (RELB-Ser151) is critical for RELB-DNA interaction and transcriptional activity. | 31399573 |
| Type | IDs |
|---|---|
| Synonymous | I-REL, IMD53, IREL, REL-B |
| Gene |
UniProtKB-ID:
RELB_HUMAN,
D6R992_HUMAN
UniprotKB:
Q01201,
D6R992
UniParc:
UPI0000141686,
UPI00000012B7
EMBL:
AF043457,
AF043455,
DQ314887,
CH471126,
BC028013,
AF043458,
AF043461,
AF043459,
AC011489,
AF043462,
M83221,
AF043460,
AF043454,
AF043456,
AF043463
Ensembl:
ENSG00000104856
KO:
hsa:5971
|
| Nucleutide sequences |
EMBL-CDS:
AAH28013.1,
AAA36127.1,
ABC40746.1,
AAC82346.1,
EAW57316.1
Gene_ORFName:
hCG_22137
Ensembl_TRS:
ENST00000625761,
ENST00000221452,
ENST00000505236
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000485826,
ENSP00000221452,
ENSP00000423287
RefSeq:
XP_005259185.1,
NP_006500.2,
XP_005259184.1
|
| Others |
UniRef100:
UniRef100_D6R992,
UniRef100_Q01201
UniRef90:
UniRef90_Q01201,
UniRef90_F1PJ94
UniRef50:
UniRef50_Q04863
UniGene:
Hs.654402
CCDS:
CCDS46110.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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