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5965 RECQL

5965

RECQL

RecQ like helicase

protein-coding

Homo sapiens

基因描述

Type Description
Definition RecQ like helicase

研究结论

Date Results Publications
2021-04-17 13:15:00 Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast 33468559
2021-03-20 13:31:00 RECQ1 Helicase in Genomic Stability and Cancer. 32517021
2020-08-15 19:06:00 RECQL5 plays an essential role in maintaining genome stability and viability of triple-negative breast cancer cells. 31231988
2020-06-27 10:40:00 Dual deficiency of MUS81 structure-specific endonuclease subunit (MUS81) and RECQ1 increased gemcitabine-induced, replication-associated DNA double-stranded breaks. 31444271
2020-01-18 11:48:00 EXD2 deficiency leads to fork collapse, hypersensitivity to replication inhibitors, and genomic instability. Impeding fork regression by inactivation of SMARCAL1 or removal of RECQ1's inhibition in EXD2(-/-) cells restores efficient fork restart and genome stability. Moreover, purified EXD2 efficiently processes substrates mimicking regressed forks. 31255466

名称对应

Type IDs
Synonymous RECQL1, RecQ1
Gene
UniProtKB-ID: RECQ1_HUMAN, A0A024RAV2_HUMAN
UniprotKB: P46063, A0A024RAV2
UniParc: UPI0000167E2F
EMBL: BT007119, AK291627, BC001052, AC006559, D37984, L36140, CH471094
Ensembl: ENSG00000004700
KO: hsa:5965
Nucleutide sequences
EMBL-CDS: AAP35783.1, EAW96434.1, BAA07200.1, AAH01052.1, AAA60261.1, BAF84316.1, EAW96438.1, EAW96436.1, EAW96437.1, EAW96435.1
Gene_ORFName: hCG_2009728
Ensembl_TRS: ENST00000421138, ENST00000444129
Protein sequencees
Ensembl_PRO: ENSP00000416739, ENSP00000395449
RefSeq: NP_002898.2, XP_005253521.1, XP_005253519.1, XP_005253520.1, NP_116559.1, XP_005253518.1
Others
UniRef100: UniRef100_P46063
UniRef90: UniRef90_P46063
UniRef50: UniRef50_P46063
UniGene: Hs.235069
CCDS: CCDS31756.1

全选

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