| Type | Description |
|---|---|
| Definition | DAN domain family member 5, BMP antagonist S homeolog |
| Date | Results | Publications |
|---|---|---|
| 2015-10-24 10:33:00 | Coco binds to TGFbeta1 and enhances TGFbeta1 binding to its receptor Alk5 thus acting as both an inhibitor and an enhancer of signaling, depending on the ligand it binds. | 26116664 |
| 2013-12-14 11:15:00 | Coco required to prevent Activin and Nodal signals in dorsal marginal side of embryo from invading the prospective ectoderm, thereby restricting endoderm- and mesoderm-inducing signals to the vegetal and marginal zones of the pre-gastrula Xenopus embryo | 24026124 |
| 2011-11-12 10:27:00 | Data suggest that Coco acts as a critical target of flow, suggesting that symmetry is broken by flow-mediated left-asymmetric release of Nodal repression at the midline. | 20381352 |
| 2010-01-21 00:00:00 | Coco directly inhibits derriere and Xnr1, and with them define a posttranscriptionally regulated signaling center which is a necessary link in the signaling chain leading to an increased TGF-beta signal on the left side of the embryo. | 17239842 |
| Type | IDs |
|---|---|
| Synonymous | 51-B6, S10-51-B6, cer2, cerl2, charon, cktsf1b3, coco, crl2, dand5, dante, grem3, xCoco |
| Gene |
UniProtKB-ID:
DAND5_XENLA
UniprotKB:
Q800X4
UniParc:
UPI0000003DA3
EMBL:
BC099052,
AF549938
KO:
xla:594864
|
| Nucleutide sequences |
EMBL-CDS:
AAO48743.1,
AAH99052.1
Gene_ORFName:
S10-51-B6
|
| Protein sequencees |
RefSeq:
NP_001092196.1
|
| Others |
UniRef100:
UniRef100_Q800X4
UniRef90:
UniRef90_Q800X4
UniRef50:
UniRef50_Q800X4
UniGene:
Xl.51884
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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