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59349 KLHL12

59349

KLHL12

kelch like family member 12

protein-coding

Homo sapiens

基因描述

Type Description
Definition kelch like family member 12

研究结论

Date Results Publications
2017-06-10 10:58:00 The interaction between the KLHL12 and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells. 27899653
2017-02-25 12:16:00 p44/42 MAPK phosphorylation, the signaling pathway which is often regulated by beta-arrestins is not influenced by KLHL12, but seems to be exclusively mediated by Galphai protein upon dopamine D4 receptor stimulation. 27155323
2016-07-02 10:18:00 KLHL12 promotes ubiquitination of the dopamine D4 receptor on non-lysine residues. 26717573
2010-01-21 00:00:00 molecular cloning and characterization of a novel gene, encoded a human kelch protein containing 568 amino acid residues, termed hDKIR. 15383316
2010-01-21 00:00:00 KLHL12 specifically interacts with the D4 polymorphism, thereby building up a Cul3-E3 ligase complex with substrate specificity toward the D4 receptor 18303015

名称对应

Type IDs
Synonymous C3IP1, DKIR
Gene
UniProtKB-ID: KLH12_HUMAN, Q9H7R2_HUMAN
UniprotKB: Q53G59, Q9H7R2
UniParc: UPI000006EE6A, UPI00002047A9, UPI0000072FF6
EMBL: AK027656, BC004175, AK223072, AK301791, BC003183, AK024412, AC096632, AF190900
Ensembl: ENSG00000117153
KO: hsa:59349
Nucleutide sequences
EMBL-CDS: BAD96792.1, AAG17175.1, AAH03183.1, BAB55271.1, BAH13554.1, AAH04175.1, BAB14914.1
Ensembl_TRS: ENST00000367261, ENST00000367259
Protein sequencees
Ensembl_PRO: ENSP00000356230, ENSP00000356228
RefSeq: NP_001290038.1, NP_001289980.1, XP_011508139.1, XP_016857484.1, XP_011508138.1, XP_011508137.1, NP_067646.1
Others
UniRef100: UniRef100_Q9H7R2, UniRef100_Q53G59
UniRef90: UniRef90_Q53G59, UniRef90_F7IDA0
UniRef50: UniRef50_Q53G59-2, UniRef50_Q53G59
UniGene: Hs.706793
CCDS: CCDS1429.1

全选

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